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https://www.selleckchem.com/products/unc1999.html 3%) had ≥1 telemedicine claim. Among children receiving care from telemedicine-using subspecialists, likelihood of any telemedicine use was increased for rural children (OR 10.4, 95%CI 6.3-17.1 compared to large metropolitan referent group) and those >90 miles from the subspecialist (OR 13.4, 95% CI 10.2-17.7 compared to 0-30 mile referent group). Compared to children receiving care from telemedicine non-using subspecialists, matched children receiving care from telemedicine-using subspecialists had larger differences in visit rates by distance to care, county rurality, ZIP code median income, and child race/ethnicity (p less then 0.001 for interaction terms). CONCLUSION Children in rural communities and at distance to subspecialists had increased likelihood of telemedicine use. Use overall was low, and results indicated that early telemedicine policies and implementation did not close disparities in subspecialty visit rates by child geographic and sociodemographic characteristics. Perimenopausal depression is caused by the impaired function of the ovarium piror to menopause and with a series of symptoms. Electroacupuncture (EA) therapy has been demonstrated to improve clinically depression. However, the mechanism underlying its therapeutic activity remains unknown. This study used chronic unpredictable mild stress (CUMS) combined with bilateral ovariectomy (OVX) to establish a rat model of perimenopausal depression, and investigated the effects of EA treatment on the hippocampal neural proliferation. Four-week EA treatment at three points including "Shenshu" (BL 23), "Baihui" (DU 20) and "Sanyinjiao" (SP 6) simultaneously ameliorated depression-like behaviors in rats with CUMS and OVX, while rescued the decreased serum level of estrogen (E2) and prevented the increased serum levels of gonadotropin releasing hormone (GnRH), luteinizing hormone (LH). EA treatment ameliorated CUMS and OVX-induced alterations of glycoge

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