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https://www.selleckchem.com/products/cep-18770.html Overexpression of LEF1-AS1, EZH2 and CDCA7 promoted proliferation and invasion in HCC cells. LEF1-AS1 promoted CDCA7 expression to further upregulate EZH2. Tumor formation in nude mice was assessed to verify the experimental results. Silencing of LEF1-AS1 inhibited the growth of tumors in vivo. Collectively, silencing LEF1-AS1 inhibited the proliferation and invasion of HCC cells by down-regulating EZH2 through the CEBPB-CDCA7 signaling pathway, which provides scientific evidence for the treatment of HCC.Abbreviations HCC Hepatocellular carcinoma; lncRNA long non-coding RNA; LEF1-AS1 lymphoid enhancer-binding factor-1 antisense RNA 1; EZH2 enhancer of zeste homolog 2; CDCA7 cell division cycle-associated 7; GEO Gene Expression Omnibus; NC negative control; oe overexpressed; RT-qPCR reverse transcription quantitative polymerase chain reaction; PBS phosphate buffered saline; HRP horseradish peroxidase; OD optical density; RIP Radioimmunoprecipitation; ChIP Chromatin immunoprecipitation; WT wild type.Background Older adults' health and quality of life, proxies for aging well, are tied to activity engagement. Recent research indicates studying the perspective of older adults through their personal stories is key to understanding the phenomenon of occupational engagement as experienced day-to-day.Aim To uncover the lived experience of older adults within their natural settings to better understand the phenomenon of activity engagement. This new knowledge informs programming options suited to older adults' wants and needs.Materials/methods Ten community-dwelling older adults (5 female, 5 male mean 79 years) were studied. Researchers performed phenomenological interpretive analysis (IPA) with multiple coders and member cheques to triangulate findings.Results Daily activities revolved around three themes 1) Perspectives of self-identity are viewed as consistent throughout the lifespan; 2) Civic engagement is beneficial for

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