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https://www.selleckchem.com/products/AZD2281(Olaparib).html This surgical method has been published around 10 times in separated reports around the world and for first time in our region. Physiological midline defects of the lumbosacral vertebral arches on radiographs must be distinguished from pathological spina bifida. To date, however, this has not been examined, except for some reports based on plain radiography. The aim of this study is to accurately define the rate and distribution of physiological defects by computed tomography (CT) imaging. A total of 115 patients aged 0months to 16years (median age, 4years) who underwent CT scans for abdominopelvic disorder not involving the lumbosacral spine were retrospectively analyzed. The lumbosacral spines were collaterally identified on these images. In the lumbosacral spine excluding the sacral hiatus, the rate of physiological defects was 66.1% (95% confidence interval [CI] 56.7-74.7%), and the mean number of defective vertebral arches was 1.6 per patient (95% CI 1.3-1.9). The rate and mean number of defects were significantly higher in the group of patients less than 6years old (84.3%, 2.2/patient) than that of patients 6years old or older (37.8%, 0.5/patient) (p < 0.001 and p < 0.001, respectively). The defect rates by spinal level were S3 (57.4%), S1 (47.8%), S2 (34.8%), L5 (13.0%), L4 (2.6%), and L3 (0.9%) in descending order. Physiological defects were found more commonly at an earlier age and predominantly existed adjacent to the sacral hiatus (S3) and around S1. Understanding the detection rate and distribution features of defects more precisely on CT images will contribute clinically supportive information to distinguish between physiological defects and pathological spina bifida. Physiological defects were found more commonly at an earlier age and predominantly existed adjacent to the sacral hiatus (S3) and around S1. Understanding the detection rate and distribution features of defects more precisely on C

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