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https://www.selleckchem.com/Bcl-2.html The relationship between self-reported visual disability and cognitive impairment in older individuals is unclear. To determine the relationship of vision-specific functioning (VSF), vision-specific mobility (VSM) and visual acuity (VA) with clinically assessed cognitive impairment in the Epidemiology of Dementia in Singapore study. Cross-sectional. Population-based. Eight hundred and seventy-four adults aged ≥60years at higher risk of possible cognitive impairment by the Abbreviated Mental Test and progressive forgetfulness question. VSF and VSM were measured using Rasch-transformed continuous scores of two Impact of Vision Impairment questionnaire domains. Cognitive impairment was objectively determined using detailed neuropsychological testing and defined as no cognitive impairment (NCI), mild cognitive impairment-no dementia (CIND), moderate CIND only and moderate CIND or dementia. Associations were assessed using multinomial logistic regression models. Of the 874 participants (49.0% males, mean age (SD) 65.5 (7.0) years), 277, 281 and 316 had NCI, mild CIND and moderate CIND or dementia, respectively. Compared to NCI, the odds of moderate CIND, and moderate CIND or dementia increased for every SD worsening in VSF (OR 1.44, 95% CI 1.14-1.82, and OR 1.52, 95%CI 1.19-1.94, respectively) and VSM (OR 1.42, 95%CI 1.11-1.81, and OR 1.50, 95%CI 1.15-1.95). Similarly, the odds of mild CIND (OR 1.62, 95%CI 1.19-2.22), moderate CIND (OR 1.93, 95%CI 1.45-2.58), and moderate CIND or dementia (OR 2.25, 95%CI 1.62-3.11) increased significantly with every SD worsening of VA. Our results emphasise the importance of interventions to prevent vision loss and improve quality of life to reduce likelihood of age-related cognitive decline. Our results emphasise the importance of interventions to prevent vision loss and improve quality of life to reduce likelihood of age-related cognitive decline. Accurate molecular diagnostic tests are necessary

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