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https://www.selleckchem.com/products/importazole.html Conclusions The emergence of the latent infection by VZV under a rare presentation might illustrate the impact at least locally of COVID-19, once retrograde reactivation of VZV was possibly induced in a young immunocompetent patient.We thank our colleagues for their constructive discussion on our recently published study1 . Regarding prevalence, indeed, growing literature yields a variable frequency of loss of smell (LOS) in Covid-19 patients, that may be hypothetically due to differences in the location and amount of viral load, to the different immune response between younger mild-symptomatic outpatients (higher prevalence) and more severely affected inpatients (lower prevalence)1,2 , and to the variable methods of measurement.The frequency of microsatellite instability (MSI) is reportedly extremely low in breast cancer, despite widespread clinical expectations that many patients would be responsive to immune-checkpoint inhibitors (ICI). Considering that some triple-negative breast cancers (TNBC) responded well to ICI in a clinical trial and that a high density of tumor-infiltrating lymphocytes (TILs) is frequently observed in other cancers with high levels of microsatellite instability (MSI-H), we hypothesized that some TNBC with a high density of TILs would be MSI-H. Medullary carcinoma (MedCa) of the breast, a rare histological type, is characterized by a high density of TILs. Considering that MedCa of the colon is often MSI-H, we suspected that MedCa in breast cancer might also include MSI-H tumors. Therefore, we conducted MSI tests on such breast cancers with a high density of TILs. The MSI status of 63 TIL-high TNBC and 38 MedCa tumors, all from Asian women who had undergone curative surgery, were determined retrospectively. DNA mismatch repair (MMR) proteins and PD-L1 expression were also investigated immunohistochemically. All samples were microsatellite stable, being negative for all microsatellite mar

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