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https://www.selleckchem.com/products/gsk8612.html PTSD symptoms of participants in the experimental group are expected to improve significantly more than those of participants in the waitlist control group (P=.05) with a large effect size (η =0.14). This is the first study to assess the relationship between e-CBT and ketamine and their combined ability to treat refractory PTSD. If successful, this study will open web-based, asynchronous therapeutic options for patients with PTSD and will provide new insights into the functional role of glutamate in trauma-related disorders as well as in learning, memory, and fear extinction. ClinicalTrials.gov NCT04771767; https//clinicaltrials.gov/ct2/show/NCT04771767. PRR1-10.2196/30334. PRR1-10.2196/30334. The use of artificial intelligence based chatbots as an instrument of psychological intervention is emerging, however no studies have been reported in Latin America. The objective of the present study was to evaluate the viability, acceptability and potential impact of Tess, a chatbot, on symptoms of depression and anxiety in university students. This was a pilot randomized controlled trial. The experimental condition used Tess for eight weeks and the control condition was assigned to a psychoeducation book on depression. Comparisons were conducted using Mann-Whitney U and Wilcoxon tests for depression symptoms, and Independent and Paired Samples t Tests to analyze anxiety symptoms. The initial sample consisted of 181 Argentinian college students (87.2% female) ages 18 to 33. A total of 39 (39%) participants in the experimental condition and 34 (41%) in the control group, provided data at week eight. There was an average of 472 (SD=249.52) messages exchanged and an average of 116 (SD=73.87) of the messages were sent from the user in response to Tess. A higher number of messages exchanged with Tess was associated with positive feedback (F2,36=4.37; P =.02). No significant intergroup differences from baseline to week eight betwee

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