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https://www.selleckchem.com/products/ms-275.html with apical lesion. Therefore, it appears that this collagen-binding protein gene plays an underestimated role in asymptomatic/chronic endodontic infections. To evaluate and compare the effects of laser monotherapy with non-surgical mechanical instrumentation alone in untreated periodontitis patients. A focused question was formulated based on the Population, Intervention, Comparison, Outcome, and Study design criteria (PICOS) in patients with untreated periodontitis, does laser mono-therapy provide adjunctive effects on pocket probing depth (PPD) changes compared with non-surgical instrumentation alone? Both randomized controlled clinical trials (RCTs) and controlled clinical trials (CCTs) were included. The results of the meta-analyses are expressed as weighted mean differences (WMD) and reported according to the PRISMA guidelines. The search yielded 1268 records, out of which 8 articles could be included. With respect to PPD changes, a meta-analysis including 5 articles (n = 148) failed to identify statistically significant differences in favor of laser monotherapy for PPDchange (WMD = 0.14 mm; 95% CI - 0.04/0.32; z = 1.51; p = 0.132) nor for clinical attachment level (CAL)(WMD = 0.04 mm; 95% CI - 0.35/0.42; z = 0.19; p = 0.850). Data on cost-effectiveness are lacking. One study reported patient-related outcome measures (PROMS). In untreated periodontitis patients, laser monotherapy does not yield superior clinical benefits compared with non-surgical mechanical instrumentation alone. In untreated periodontitis patients, mechanical instrumentation with hand and/or ultrasonic instruments remains the standard of care. In untreated periodontitis patients, mechanical instrumentation with hand and/or ultrasonic instruments remains the standard of care. Thrombotic microangiopathy (TMA) in systemic lupus erythematosus is a rare manifestation associated with activation of the complement system. This study aimed to compare p

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