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https://www.selleckchem.com/products/LBH-589.html PURPOSE To evaluate the psychometric properties of the Chinese version of the Hypoglycemia Fear SurveyII (HFS-II) in patients with type 2 diabetes mellitus from Tianjin City. METHODS The original HFS-II was translated and adapted to Chinese.350 inpatients from five hospitals of Tianjin completed the Chinese HFS-II. We examined the validity (content and construct validity) and reliability (internal consistency and test-retest reliability) of the scale. Content validity was evaluated by the content validity index (CVI) and the average agreement CVI(S-CVI/Ave). The construct validity was assessed by exploratory factor analysis. Reliability was measured by intraclass correlation coefficient (ICC) and Cronbach's alpha. RESULTS The mean age of the 350 patients was 55.5±9.3years. The CVI was 0.71~1.0 and S-CVI/Ave was 0.92 respectively. By exploratory factor analysis, four factors were extracted which accounted for 52.15% of the total variance in the 23-item scale. The Chinese HFS-II displayed good internal consistency (Cronbach's alpha = 0.90) and test-retest reliability (ICC = 0.96). CONCLUSIONS The Chinese version of HFSII had excellent psychometric properties and it could provide a useful tool for clinicians and nursing staff to assess the fear of hypoglycemia.A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. Here, we combined an experimental model with the transcriptional profile of human VL to demonstrate that the TLR4-IFN-β pathway regulates the chronic inflammatory process and is associated with the asymptomatic form of the disease. Tlr4-deficient mice harbored fewer parasites in their spleen and liver than wild-type mice. TLR4 deficiency enhanced the Th1 immune response against the parasite, which was correlated with an

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