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https://www.selleckchem.com/products/epz-6438.html To report the clinical features, treatment strategy, and mortality of patients with endogenous panophthalmitis (EP). Fifteen patients (16 eyes) diagnosed with EP from December 2012 to December 2018 were investigated with a standard protocol at a tertiary medical center of the largest eye center in Northern China. Mortality was followed up. All participants were Han Chinese. The mean age was 58.3, 62.5% were male, and 93.3% were unilaterally involved. The average number of predisposing factors was 3.0. The top two predisposing factors were diabetes mellitus (DM, 93.3%) and pyogenic liver abscess (PLA, 66.7%). All patients initially presented at an ophthalmic emergency due to severe ocular symptoms. All patients were co-managed by relevant specialists and were admitted to medical or surgical wards instead of the eye center unless the systemic condition was well controlled. Only four eyes were eligible for vitrectomy. The mean follow-up duration was 12.5months. The mortality rate was 0%. The predominant capredispose its development. The predominant causative organism was Klebsiella pneumoniae. The interdisciplinary cooperation system of the management of EP may reduce the mortality rate.Abbreviations EP endogenous panophthalmitis; EE endogenous endophthalmitis; DM diabetes mellitus; PLA pyogenic liver abscess; ACI acute cerebral infarction; UTI urinary tract infection; ICU intensive care unit; VA visual acuity; LP light perception; HM hand motion; NLP no light perception; K. pneumoniae Klebsiella pneumoniae; CT computed tomography; MRI magnetic resonance imaging; CRP C-reactive protein; PCT procalcitonin; FBG fasting blood glucose; WBC white blood cell; NEUT neutrophil proportion; BDG 1,3-β-D-glucan; GM galactomannan; IVI intravitreal injection; PPV pars plana vitrectomy; ILAS invasive liver abscess syndrome; cps capsular polysaccharide; CSF cerebrospinal fluid; SD standard deviation.A cross-sectional study was conduct

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