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https://www.selleckchem.com/products/remdesivir.html From these, design examples are provided for HSP-90, cathepsin K, and TIE-2 kinase. A further study involved the searching for possible drug targets for unusual pyridopyrimidine cores. This process resulted in the identification of potential novel HIV reverse transcriptase inhibitors which were synthesized and shown to exhibit similar in vitro potencies to marketed compounds. Overall, the methodology described provides a powerful new approach to identify new target opportunities for scaffolds of provenance.Whereas the self-assembly of pentaphosphaferrocenes [CpRFe(η5-P5)] (CpR = Cp*, Cp×, and CpBn) with Cu and Ag salts has been well-studied in the past, the coordination chemistry toward Au complexes has been left untouched so far. Herein, the results of the self-assembly processes of [CpRFe(η5-P5)] with Au salts of different anions (GaCl4-, SbF6-, and Al(OC(CF3)3)4 (TEF-)) are reported. Next to a variety of molecular coordination products, the first coordination polymers based on polyphosphorus ligand complexes and Au salts are also obtained. Thereby, a 2D coordination polymer comprising metal vacancies is isolated. In all products, the Au centers are coordinated in a linear or a trigonal planar environment. In solution, highly dynamic processes are observed. Variable-temperature NMR spectroscopy, solid-state NMR spectroscopy, and X-ray powder diffraction were applied to gain further insight into selected coordination compounds.Two metal-organic frameworks (MOFs), UiO-66 and UiO-66-NH2, were considered as containers for bioactive chemicals. We provide a synthesis technique, which allowed the production of these materials suitable for biomedical applications. Both MOFs were characterized as single-phase porous materials composed of nanoparticles (30-65 nm) with a ζ-potential of more than 40 mV in water suspension. D,L-Leucine was applied as a model molecule, which allowed us to trace the mechanism of the loading pr

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