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https://www.selleckchem.com/products/pf-04620110.html ating the expression of p27. IJCEP Copyright © 2020.The P2X7 receptor (P2X7R) is an exclusive member of the purinergic receptor family that plays a key role in tumor progression, including colorectal cancer (CRC). P2X7R supports the tumor cells to resist unfavorable conditions by stimulating GLUT-1 expression. GLUT1 is the major glucose transporter in CRC cells and is indicated to be a poor prognostic indicator in patients with CRC. Recently, P2X7R and GLUT-1 are being investigated as prognostic biomarkers in the development of new treatment options. In this study, we aimed to investigate the prognostic value of P2X7R and GLUT-1 expression in CRC. We examined P2X7R and GLUT-1 expression in specimens of 196 CRC patients, immunohistochemically. P2X7R expression was higher in patients with poorly differentiated tumors than in those with well differentiated ones (P = 0.001). P2X7R and GLUT-1 overexpression were correlated to TILs (P less then 0.001; P = 0.028, respectively), depth of invasion (P less then 0.001; P = 014, repectively), distant metastasis (P less then 0.001), and advanced TNM stage (P less then 0.001). Moreover, multivariate Cox regression analysis showed that P2X7R overexpression clearly correlated with worsened overall survival (HR 4.69; 95% CI 1.77-12.41; P = 0.002). Similarly, patients with GLUT-1 overexpression showed shorter overall and disease-free survival than those with low expression. Our data support that P2X7R and GLUT-1 may be used as an independent prognostic markers and may present new options in terms of targeted therapies for CRC patients. IJCEP Copyright © 2020.The stability of retained austenite was improved by the dual-stable C-Mn partitioning process. The phase transformation and element diffusion of dual-stable C-Mn partitioning process of tested steel were investigated by means of EPMA, SEM, OM, tensile testing machine, and other analysis methods. The effects of the first and se

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