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https://www.selleckchem.com/JAK.html rsistent kidney dysfunction. Pregnancies in women with regurgitant valve lesions are generally considered low risk, but this has not been well studied. This study determined the frequency of adverse cardiac events (CEs) in pregnant women with moderate or severe regurgitant valve lesions. Maternal and fetal outcomes in women with moderate or severe chronic valve regurgitation enrolled in a prospective multicenter study on pregnancy outcomes were examined. Adverse CEs included heart failure, sustained arrhythmias, cardiac arrest, or death. A multivariate logistic regression model was used to identify determinants of CEs in women at the highest risk. Outcomes of 430 pregnancies in women with moderate or severe regurgitant lesions were examined 145 with mitral regurgitation (MR), 101 with pulmonary regurgitation (PR), 71 with multivalve disease, 73 with tricuspid regurgitation (TR), and 40 with aortic regurgitation (AR). Most women had associated congenital or acquired heart disease. Adverse CEs occurred in 13% of pregnancies 27% of g and pregnancy planning. Obesity is a well-established risk factor for heart failure (HF). However, implications of pericardial fat on incident HF is unclear. This study sought to examine the association between pericardial fat volume (PFV) and newly diagnosed HF. This study ascertained PFV using cardiac computed tomography in 6,785 participants (3,584 women and 3,201 men) without pre-existing cardiovascular disease from the MESA (Multi-Ethnic Study of Atherosclerosis). Cox proportional hazards regression was used to evaluate PFV as continuous and dichotomous variable, maximizing the J-statistic (Sensitivity+ Specificity - 1). In 90,686 person-years (median 15.7 years; interquartile range 11.7 to 16.5 years), 385 participants (5.7%; 164 women and 221 men) developed newly diagnosed HF. PFV was lower in women than in men (69 ± 33cm vs. 92 ± 47cm ; p<0.001). In multivariable analyses, every 1-SD (42cm ) inc

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