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https://www.selleckchem.com/products/Paclitaxel(Taxol).html © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND AND AIMS The development of cirrhosis-related smartphone applications for remote monitoring is increasing. Whether patients with cirrhosis will welcome such new technology, however, is uncertain. METHODS We prospectively enrolled patients with cirrhosis (N = 102) to determine predictors of acceptance and utilization of a smartphone application for cirrhosis management using a 12-item Technology Acceptance Model (TAM) survey. Patients were then shown the EncephalApp© and evaluated for their willingness to download and use the application. RESULTS Patients had a median age of 61.3 years and 63.7% had a history of hepatic decompensation. Intention to use the hypothetical application was associated with perceived usefulness (β 0.4, 95% CI 0.3-0.5) and the presence of a caregiver (β 1.1, 95% CI 0.2-2.0). Of the eligible participants, 71% agreed to download the EncephalApp© and the decision was influenced by computer anxiety, behavioural intent, caregiver presence and disease state factors. Actual usage was 32% and not associated with baseline characteristics or the technology acceptance model. CONCLUSIONS Patient acceptance of smartphone applications for the management of cirrhosis is high and related to their attitudes towards technology and the presence of a caregiver. However, usage was low. Future research must employ behavioural interventions to optimize uptake and utilization of remote monitoring technology. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.Biological ion channels and ion pumps with sub-nanometer sizes modulate ion transport in response to external stimuli. Realizing such functions with sub-nanometer solid-state nanopores have been an important topic with wide practical applications. Herein, we demonstrate biomimetic photoresponsive ion channel and photodriven ion pump using porphyrin-based metal-organic framework

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