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https://www.selleckchem.com/products/sr59230a.html 52 (0.63--0.31), respectively. In addition to the assessment of Tregs by phenotype, six out of the 18 included studies investigated the functionality of these cells. These studies showed a lower inhibitory effect of Tregs cells on the proliferation of effector T cells of women with RM compared to fertile women. Also, the expression of IL-10 and TGF-beta was diminished. This systematic review shows that Treg levels and their function are significantly decreased in peripheral blood and decidua of pregnant and non-pregnant women with RM. This underlines the hypothesis that Tregs play a role in the pathogenesis of RM. Despite the multidimensional/ecological integrative perspective that suggests that the risk for problem gambling in adolescents can be determined by an interactive effect of different risk factors, few studies have investigated how different individual factors may affect the risk for problem gambling in a multiplicative way. This study aimed at exploring the interaction between immigrant status (IS) and sensation seeking (SS) on adolescent problem-gambling severity. The study involved 994 Italian adolescents (64% boys, Mage = 16.57, SD = 1.62). Participants' IS, SS and problem-gambling severity were individually assessed through, respectively, a socio-demographic questionnaire, the Brief Sensation Seeking Scale (BSSS) and the South Oaks Gambling Screen - Revised for Adolescents (SOGS-RA). Results showed that, among immigrant adolescents, there were higher levels of problem-gambling severity and a higher distribution of at-risk and problem gamblers with respect to non-immigrant adolescents. Both IS and SS had significant direct effects on problem-gambling severity, with IS and higher levels of SS being predictors of greater severity. A moderation analysis - controlling for gender and age - showed that adolescents with high scores of SS were more prone to experience gambling problems if they were also immigr

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