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https://www.selleckchem.com/products/bay-1895344-hcl.html Psychoacoustic research suggests that judgments of perceived loudness change differ significantly between sounds with continuous increases and decreases of acoustic intensity, often referred to as "up-ramps" and "down-ramps." The magnitude and direction of this difference, in turn, appears to depend on focused attention and the specific task performed by the listeners. This has led to the suspicion that cognitive processes play an important role in the development of the observed context effects. The present study addressed this issue by exploring neural correlates of context-dependent loudness judgments. Normal hearing listeners continuously judged the loudness of complex-tone sequences which slowly changed in level over time while auditory fMRI was performed. Regression models that included information either about presented sound levels or about individual loudness judgments were used to predict activation throughout the brain. Our psychoacoustical data confirmed robust effects of the direction of intensity change on loudness judgments. Specifically, stimuli were judged softer when following a down-ramp, and louder in the context of an up-ramp. Levels and loudness estimates significantly predicted activation in several brain areas, including auditory cortex. However, only activation in nonauditory regions was more accurately predicted by context-dependent loudness estimates as compared with sound levels, particularly in the orbitofrontal cortex and medial temporal areas. These findings support the idea that cognitive aspects contribute to the generation of context effects with respect to continuous loudness judgments.Telomeres consist of repetitive DNA sequences and telomere-associated proteins. Telomeres located at the ends of eukaryotic chromosomes undergo shortening due to DNA replication, genotoxic factors and reactive oxygen species. The short telomeres are elongated by the enzyme telomerase expressed

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