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https://www.selleckchem.com/products/sanguinarine-chloride.html A series of fluorescent dibenzodiazepinone-type muscarinic acetylcholine M2 receptor (M2R) ligands was synthesized using various fluorescent dyes (5-TAMRA, λex/λem ≈ 547/576 nm; BODIPY 630/650, λex/λem ≈ 625/640 nm; pyridinium dye Py-1, λex/λem ≈ 611/665 nm and pyridinium dye Py-5, λex/λem ≈ 465/732 nm). All fluorescent probes exhibited high M2R affinity (pKi (radioligand competition binding) 8.75-9.62, pKd (flow cytometry) 8.36-9.19), a very low preference for the M2R over the M1 and M4 receptors and moderate to pronounced M2R selectivity compared to the M3 and M5 receptors. The presented fluorescent ligands are considered useful molecular tools for future studies using methods such as fluorescence anisotropy and BRET based MR binding assays.Guavanoic acid functionalized gold nanoparticles exhibit anti-diabetic potential by improving insulin dependent glucose uptake in L6 rat skeletal muscle cells. The mode of action of the gold nanoparticles was established from the glucose uptake assay in the presence and absence of genistein and wortmannin. The anti-diabetic efficacy of guavanoic acid functionalized gold nanoparticles was put forth by in vitro assays like for PTP 1B, α-amylase and α-glucosidase enzyme activities. Studies on cytotoxicity revealed 50% inhibition of cells at 265 ± 0.01 μg mL-1. In the LDH enzyme release assay on differentiated L6 myoblasts treated with different concentrations (1-100 μg mL-1) of guavanoic acid functionalized gold nanoparticles, a viability of 75% at 100 μg mL-1 was observed.RNA molecules are becoming an important target class in drug discovery. However, the principles for designing RNA-binding small molecules are yet to be fully uncovered. In this study, we examined the Protein Data Bank (PDB) to highlight privileged interactions underlying small molecule-RNA recognition. By comparing this analysis with previously determined small molecule-protein interactions, we find

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