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https://www.selleckchem.com/products/pf-06826647.html A simple and rapid reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay was developed for the detection of SARS-CoV-2. The RT-LAMP assay was highly specific for SARS-CoV-2 and was able to detect one copy of transcribed SARS-CoV-2 RNA within 24 minutes. Assay validation performed using 50 positive and 32 negative clinical samples showed 100% sensitivity and specificity. The RT-LAMP would be valuable for clinical diagnosis and epidemiological surveillance of SARS-CoV-2 infection in resource-limited areas as it does not require the use of sophisticated and costly equipment. It is believed that radiotherapy has important effects on oxidant/antioxidant systems. Oxidative stress occurs when the balance between oxidant formation and antioxidant defense is disrupted in favour of oxidants. The aim of this study was to determine the biochemical changes in saliva pre- and post-radiotherapy in head-neck radiotherapy patients and to find out the effects of radiation on glutathione (GSH), glutathione peroxidase (GSH-Px), and Malondialdehyde (MDA) levels in saliva. This study included 16 patients undergoing head-neck radiotherapy in the Atatürk University Research Hospital. The levels of GSH, GSH-Px, and MDA were measured in saliva samples taken from the patients pre- and post-radiotherapy. The same biochemical parameters were also measured in saliva samples from 30 healthy individuals who did not undergo head-neck radiotherapy. The data obtained were analysed using the paired t-test and the Mann-Whitney U test. When the levels of GSH (p > 0.05), GSH-Px (p > 0.05), and MDA (p < 0.05) in saliva were compared pre- and post-radiotherapy in the patient group, the only significant increase was detected in MDA level post-radiotherapy. When the pre- and post-radiotherapy levels of saliva GSH (p < 0.01, p < 0.001, respectively), GSH-Px (p > 0.05, p < 0.05, respectively), and MDA (p < 0.01, p < 0.001, respectivel

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