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https://www.selleckchem.com/products/vls-1488-kif18a-in-6.html Background and aim Antibiotic resistance is a global public health problem. Around 55% of dental antibiotic prescribing is deemed inappropriate. The aim of this multimodal interventional pilot study was to assess the effect on prescribing of education and a dentally-designed prescribing website. Methods Twenty-six dentists were recruited for the 12-week study using a pre-post design. Dentists self-recorded their prescribing of antibiotics, analgesics and anxiolytics for six weeks. After dentists were provided education and website access, they recorded their prescribing for a further six weeks. Four outcomes were measured comparing the prescribing before and after the intervention 1) the number of inappropriate indications for which antibiotics were prescribed; 2) the number of prescriptions 3) accuracy of the prescriptions according to the Australian therapeutic guidelines and 4) the confidence of practitioners towards the prescribing website. Participants were interviewed for feedback. Results There was a substantial reduction of 44.6% in the number of inappropriate indications for which antibiotics were prescribed after the intervention and a decrease of 40.5% in the total number of antibiotics. Paracetamol with codeine substantially reduced by 56.8%. For the three most commonly prescribed antibiotics (amoxicillin, phenoxymethylpenicillin and metronidazole), there was the improvement in the accuracy of the prescriptions ranging from 0-64.7% to 74.2-100%. Conclusion This pilot study showed the intervention of targeted education and the prescribing website was effective in improving dental prescribing, knowledge and confidence of practitioners, as well as providing an effective antibiotic stewardship tool. This context-specific intervention shows substantial promise for implementation into dental practice.Oral cancer causes significant global mortality and has a five-year survival rate of around 64%. Po

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