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https://www.selleckchem.com/products/arv-110.html The purpose of this study was to evaluate baseline best corrected visual acuity (BCVA), full-field electroretinography (ERG), full-field stimulus thresholds (FST), and their relationship with baseline demographic and clinical characteristics in the Rate of Progression in Usher syndrome type 2 ( )-related Retinal Degeneration (RUSH2A) multicenter study. Participants had Usher syndrome type 2 (USH2, = 80) or autosomal recessive nonsyndromic retinitis pigmentosa (ARRP, =47) associated with biallelic variants in the gene. Associations of demographic and clinical characteristics with BCVA, ERG, and FST were assessed with regression models. In comparison to ARRP, USH2 had worse BCVA (median 79 vs. 82 letters; < 0.001 adjusted for age), lower rod-mediated ERG b-wave amplitudes (median 0.0 vs. 6.6µV; < 0.001) and 30 Hz flicker cone-mediated ERG amplitudes (median 1.5 vs. 3.1 µV; =0.001), and higher (white, blue, and red) FST thresholds (means [-26, -31, -23dB] vs. [-39, -45, -28dB]; &lts with USH2A mutations. Choroidal thickness (ChT) and choroidal vascularity index (CVI) represent two important metrics in health-, disease-, and myopia-related studies. Wide-field swept-source optical coherence tomography (OCT) provides improved and extended imaging and extraction of choroidal variables. This study characterizes the topography and repeatability of these parameters in healthy eyes. Swept-source OCT volume scans were obtained on 14 young adult patients on three separate days. ChT and CVI were automatically corrected for image magnification and extracted for different enface regions within an extended ETDRS grid of 10mm diameter. Topographical distribution, correlation to ocular length, and intersession repeatability of both choroidal parameters were assessed. CVI showed little fluctuation between subfields, unlike ChT, which demonstrated thinning toward the peripheral choroid (coefficients of variation 5.92 vs. 0.89). ChT showe

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