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https://www.selleckchem.com/screening/natural-product-library.html Laparoscopic sleeve gastrectomy is now the most commonly performed bariatric surgery. Although considered a safe procedure, adverse events such as staple line leak in the context of sleeve stenosis can result in significant patient morbidity and health economic burden. Correction of the downstream stenosis is mandatory for closure of the staple line leak. Conventional endoscopic therapies offer high initial success rates, though ultimately a significant proportion proceed to revision surgery. Gastric per-oral endoscopic myotomy (G-POEM) is a novel, minimally invasive procedure which allows for a full-thickness myotomy of the stenosed segment, potentially conferring similar anatomical correction to surgical seromyotomy. We present a case of recalcitrant chronic proximal staple line leak in the context of a downstream gastric stenosis managed by G-POEM. This retrospective study reviews the maxillofacial fractures (MF) over a 5-year period at the National Maxillofacial Unit, St James Hospital Dublin, with an emphasis on female patients. The trauma database was analysed from January 2015 to December 2019. The following demographic details were recorded patient age and gender, mechanism of injury, and facial fracture sites. This retrospective study did not require approval from the local IRB. A total of 4761 patients had facial fractures during the study 1125 (24%) female, 3636, (76%) male. Females had 1190 facial fractures, with two fracture peaks 20-39years and 70-89years. In males, the majority of fractures occurred between 20 and 39 peaking at 20-29years and tailed off thereafter. In the females the most common fracture sites were zygomatic 402 (34%), nasal 311(26%), orbital (22%), and mandibular 141(12%). There were also smaller percentages of frontal (0.8%), maxillary (4%), and Le Fort fractures (1%). Two hundred and sixty-two (23%) females were manault. There is an informal concern amongst maxillof

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