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https://www.selleckchem.com/products/3-typ.html Joint preservation strategies in young, active patients are a challenge, particularly in those with combined cartilage and meniscal deficiency. Concomitant malalignment and/or ligamentous insufficiency are not uncommon and further add to the complex nature of these patients. In patients who require surgery, a complete treatment strategy must be developed and implemented because unaddressed pathology typically leads to poor outcomes over time. In addition to reconstructive procedures, biologic therapies both as nonsurgical treatments and surgical augments offer promise, but their indications and place in orthopaedics continue to evolve. A comprehensive approach to this difficult patient population, including understanding all underlying pathologies, the natural history of each condition, and the appropriate treatment for each pathology, is necessary for successful joint preservation treatment in the young and active population.Meniscal pathology is one of the most common structural knee issues seen and managed by the orthopaedic surgeon. An ever-evolving armamentarium of management options exists that are geared toward the elimination of symptoms and restoration of normal knee function. A common theme among these management options is to preserve meniscal tissue whenever possible through repair or minimization of meniscal excision, as the literature has shown that the loss of meniscal tissue can significantly alter the distribution of forces and contact stresses on knee articular cartilage, thus predisposing the joint to degenerative osteoarthritis. In the setting of meniscal injuries or insufficiency, various advances in repair techniques, use of meniscal allografts, and use of biologic adjuvants have been reported to help preserve and/or attempt to restore the native kinematic properties of the knee. It is important to explore meniscal function, its associated pathologies, and currently available treatment options tha

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