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https://www.selleckchem.com/products/imlunestrant.html Our results can be attributed to the existence of terpenes and sesquiterpene lactones, which are likely inhibitors of AChE, in T. diversifolia.MAPK-activated protein kinase 2 (MK2) has diverse roles in cancer. In response to chemotherapy, MK2 inhibition is synthetically lethal to p53-deficiency. While TP53 deletion is rare in glioblastomas, these tumors often carry TP53 mutations. Here, we show that MK2 inhibition strongly attenuated glioblastoma cell proliferation through p53wt stabilization and senescence. The senescence-inducing efficacy of MK2 inhibition was particularly strong when cells were co-treated with the standard-of-care temozolomide. However, MK2 inhibition also increased the stability of p53 mutants and enhanced the proliferation of p53-mutant stem cells. These observations reveal that in response to DNA damaging chemotherapy, targeting MK2 in p53-mutated cells produces a phenotype that is distinct from the p53-deficient phenotype. Thus, MK2 represents a novel drug target in 70% glioblastomas harboring intact TP53 gene. However, targeting MK2 in tumors with TP53 mutations may accelerate disease progression. These findings are highly relevant since TP53 mutations occur in over 50% of all cancers.Local water governance is challenging given the significance to public health and the difficulties to manage it in a fragmented administrative system. A collaboration network is a popular governance tool in local governance to cope with functional fragmentation problems and institutional collective action (ICA) dilemmas. Empirical works are needed to examine the outcomes of such governance networks, especially in the context of environmental governance. With fuzzy-set qualitative comparative analysis (fsQCA), this article seeks to evaluate the outcomes of collaboration networks by investigating the influence of network structures on local water governance performance in China. Based on empirical analyses on

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