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https://www.selleckchem.com/ The oxidative biomarkers in liver and gill tissues of NPs-exposed fish showed significant (p less then 0.05) reduction in glutathione-reduced content and elevation in thiobarbituric acid reactive substances, glutathione peroxidase, catalase, and superoxide dismutase. Based on our results, Fe2O3 NPs were more toxic than Al2O3 NPs. The combined doses of both NPs showed more or less toxicity compared to single doses. Therefore, this point needs more studies to show the mode of interaction. Finally, rice husk was a good adsorber to both NPs as it could improve the biochemical and antioxidant status of the studied fish.PURPOSE Aromatase inhibitors (anastrozole, letrozole) and selective estrogen receptor modulators (tamoxifen) are widely used as adjuvant hormonal therapy in women with hormone receptor-positive breast cancer. We aimed to evaluate the effects of oral adjuvant hormonotherapy on tear functions in patients with breast cancer. METHODS In this case-control study, we enrolled eligible patients with breast cancer who were receiving regular medical selective estrogen receptor modulator (tamoxifen, n50), aromatase inhibitors (anastrozole, letrozole, n50) and gender-matched healthy controls (n50). Tear functions were measured and compared by the Schirmer test, fluorescein breakup time, corneal staining evaluated by Oxford grading scale and Ocular Surface Disease Index scores. RESULTS Mean age was 49.95 (± 9.2), 51.52 (± 7.2) and 51.91 (± 10.3) in tamoxifen, aromatase inhibitors groups and controls (p = 0.426). Mean duration of BC diagnosis (p = 0.536) and drug use (p = 0.417) was not significant between two groups. Ocular Surface Disease Index scores were lower (p less then 0.001), and fluorescein breakup time measurements were higher (p less then 0.001) in controls. Schirmer test scores were higher in controls than aromatase inhibitors group (p less then 0.001). According to the scores of all measurements, the differences between
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