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https://www.selleckchem.com/products/l-ascorbic-acid-2-phosphate-sesquimagnesium-salt-hydrate.html BACKGROUND Cardiac tamponade with acute type A aortic dissection (AADA) can cause fatal outcomes. We previously reported excellent outcomes using percutaneous pericardial drainage with controlled volumes of aspirated pericardial effusion (controlled pericardial drainage CPD) to stabilize patients with critical cardiac tamponade. This study evaluates the early and late outcomes using this approach. METHODS Between 9/03 and 7/18, 308 patients with AADA were treated surgically, including 76 patients who were presented with cardiac tamponade on arrival at hospital. Forty-nine patients who did not respond to intravenous volume resuscitation underwent CPD in the emergency room, including 14 patients (28.6%) who presented with cardiopulmonary arrest (CPA). After CPD, 39 patients (79.6%) were transferred to the operating room to undergo immediate aortic repair. The remaining 10 patients (20.4%) received medical treatment on arrival, followed by aortic repair within several days. RESULTS In 49 patients, the mean systolic blood pressure before CPD was 64.4 ± 10.3 mmHg. Blood pressure rose significantly in all patients after CPD. The total volume of aspirated pericardial effusion was 46.8 ± 56.2 ml, and 30 of the 49 patients (61%) required only 30ml or less of aspiration to improve their blood pressure. All of the patients underwent successful aortic repair. Early hospital mortality was 16%. However, mortality related to CPD was zero. The mean follow-up periods were 52.9 ± 54.3 months. The cumulative survival rate was 63.4% after five years. CONCLUSIONS Controlled pericardial drainage for critical cardiac tamponade with acute type A aortic dissection produced satisfactory early and late outcomes. BACKGROUND Transcatheter Aortic Valve Replacement (TAVR) has evolved as an alternative therapy to open AVR in most patients with aortic stenosis. Stroke associated with TAVR can be a dev

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