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https://www.selleckchem.com/products/dwiz-2.html To report uveal melanoma (UM) metastasis to the contralateral ocular and periocular structures. Retrospective study. Thirteen patients with UM metastasis to the contralateral ocular and periocular structures were included. Clinical records were reviewed retrospectively. The development and time to onset of contralateral ocular and periocular metastasis, systemic metastasis, and death. Of the 13 000 treated UM patients, 13 patients were diagnosed with UM metastasis to the contralateral ocular and periocular structures. Mean patient age at primary UM diagnosis was 60 years (median, 60 years; range, 37-87 years). The primary uveal melanoma was in the choroid (n= 11) or ciliary body (n= 2) and was treated with brachytherapy (n= 11), proton beam radiotherapy (n= 1), or enucleation (n= 1). Systemic metastasis developed in 11 patients (85%) at a mean of 66 months (median, 34 months; range, 12-216 months) after diagnosis of the primary UM. All 11 patients (100%) showed liver metastasis and 8 patients (62%as a result of systemic UM metastasis (n= 10) or unrelated cause (n= 1). Metastasis resulting from UM to the contralateral ocular and periocular structures is rare and generally occurs in patients with disseminated metastasis. Orbital tissue is the most common site of involvement, and these patients have short life expectancy. Metastasis resulting from UM to the contralateral ocular and periocular structures is rare and generally occurs in patients with disseminated metastasis. Orbital tissue is the most common site of involvement, and these patients have short life expectancy.Since the recent controversy about vaginal mesh implants, surgeons should use safe and effective devices and procedures to treat female stress urinary incontinence (SUI). We propose to describe the noninvasive and ambulatory technique of the urethral bulking procedure. Bulking agents are a simple, minimally invasive technique that can be offered in the

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