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https://www.selleckchem.com/Androgen-Receptor.html 9 [SD 15.6], 2.5 mg twice a day -10.6 [SD 7.7]), placebo -5.7 (SD 10.2); P  less then  .005 for both oxybutynin doses vs placebo), HF frequency (5 mg twice a day -7.5 [SD 6.6], 2.5 mg twice a day -4.8 [SD 3.2], placebo -2.6 [SD 4.3]; P  less then  .003 for both oxybutynin doses vs placebo), and improvement in most HF-related daily interference scale measures and in overall quality of life. Patients on both oxybutynin arms reported more side effects than patients on placebo, particularly dry mouth, difficulty urinating, and abdominal pain. Most side effects were grade 1 or 2. There were no differences in study discontinuation because of adverse effects. Conclusion Oxybutynin is an effective and relatively well-tolerated treatment option for women with HFs. © The Author(s) 2020. Published by Oxford University Press.Background Talazoparib is a poly(adenosine diphosphate-ribose) polymerase inhibitor that causes death in cells with breast cancer susceptibility gene 1 or 2 (BRCA1/2) mutations. Methods EMBRACA (NCT01945775) was a randomized phase III study comparing efficacy, safety, and patient-reported outcomes (PROs) of talazoparib (1 mg) with physician's choice of chemotherapy (PCT capecitabine, eribulin, gemcitabine, vinorelbine) in locally advanced or metastatic breast cancer with a germline BRCA1/2 (gBRCA1/2) mutation. Prespecified patient subgroups were analyzed for progression-free survival, objective response, clinical benefit, duration of response, and safety. PROs were evaluated in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) or triple-negative breast cancer (TNBC) subgroups. Results Of 431 patients, 287 were randomly assigned to talazoparib and 144 to PCT. Prespecified subgroup analyses showed prolonged progression-free survival with talazoparib (HR+/HER2- hazard ratio = 0.47, 95% confidence interval = 0.32 to 0.71; TNBC hazard ratio = 0.60, 95% confidence interval

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