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https://www.selleckchem.com/products/gdc-0084.html The development of tissue-engineered blood vessels provides a new source of donors for coronary artery bypass grafting and peripheral blood vessel transplantation. Fibrin fiber has good biocompatibility and is an ideal tissue engineering vascular scaffold, but its mechanical property needs improvement. We mixed polyurethane (PU) and fibrin to prepare the PU/fibrin vascular scaffolds by using electrospinning technology in order to enhance the mechanical properties of fibrin scaffold. We investigated the morphological, mechanical strength, hydrophilicity, degradation, blood and cell compatibility of PU/fibrin (0100), PU/fibrin (595), PU/fibrin (1585) and PU/fibrin (2575) vascular scaffolds. Based on the results in vitro, PU/fibrin (1585) was selected for transplantation in vivo to repair vascular defects, and the extracellular matrix formation, vascular remodeling, and immune response were evaluated. The results indicated that the fiber diameter of the PU/fibrin (1585) scaffold was about 712nm. With the iokines decreased. PU/fibrin (1585) vascular scaffolds had great potential to be used as small-diameter tissue engineering blood vessels. PU/fibrin (1585) vascular scaffolds had great potential to be used as small-diameter tissue engineering blood vessels.Polymeric nanomaterials have become a prominent area of research in the field of drug delivery. Their application in nanomedicine can improve bioavailability, pharmacokinetics, and, therefore, the effectiveness of various therapeutics or contrast agents. There are many studies for developing new polymeric nanocarriers; however, their clinical application is somewhat limited. In this review, we present new complex and multifunctional polymeric nanocarriers as promising and innovative diagnostic or therapeutic systems. Their multifunctionality, resulting from the unique chemical and biological properties of the polymers used, ensures better delivery, and a controlled, s

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