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https://www.selleckchem.com/ The phage TETs favor Gp5mC dinucleotides over the 5mCpG sites targeted by the eukaryotic TETs and are found within gene clusters specifying complex cytosine modifications that may be important for DNA packaging and evasion of host restriction.Are women more likely to quit politics after losing their first race than men? Women's first-time candidacies skyrocketed in the wake of the 2016 presidential election. Yet we have little sense of the long-term impact of this surge in women candidates on women's representation writ large Inexperienced candidates are more likely to lose, and women might be especially discouraged by a loss. This might make the benefits of such a surge in candidacies fleeting. Using a regression discontinuity design and data that feature 212,805 candidates across 22,473 jurisdictions between 1950 and 2018, we find that women who narrowly lose these elections are no more likely to quit politics than men who narrowly lose. Drawing on scholarship on women's lower political ambition, we interpret these findings to mean that women's decision-making differs from men's at the point of entry into politics-not at the point of reentry.Multicomponent immune receptors are essential complexes in which distinct ligand-recognition and signaling subunits are held together by interactions between acidic and basic residues of their transmembrane helices. A 21 acidic-to-basic motif in the transmembrane domains of the subunits is necessary and sufficient to assemble these receptor complexes. Here, we study a prototype for these receptors, a DAP12-NKG2C 21 heterotrimeric complex, in which the two DAP12 subunits each contribute a single transmembrane Asp residue, and the NKG2C subunit contributes a Lys to form the complex. DAP12 can also associate with 20 other subunits using a similar motif. Here, we use molecular-dynamics simulations to understand the basis for the high affinity and diversity of interactions in this group of receptors. Si

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