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https://www.selleckchem.com/products/tvb-3664.html Recent neurophysiological theories propose that the cerebral hemispheres collaborate to resolve the complex temporal nature of speech, such that left-hemisphere (or bilateral) gamma-band oscillatory activity would specialize in coding information at fast rates (phonemic information), whereas right-hemisphere delta- and theta-band activity would code for speech's slow temporal components (syllabic and prosodic information). Despite the relevance that neural entrainment to speech might have for reading acquisition and for core speech perception operations such as the perception of intelligible speech, no study had yet explored its development in young children. In the current study, speech-brain entrainment was recorded via EEG in a cohort of children at three different time points since they were 4-5 to 6-7 years of age. Our results showed that speech-brain entrainment occurred only at delta frequencies (0.5 Hz) at all testing times. The fact that, from the longitudinal perspective, coherence increased in bilateral temporal electrodes suggests that, contrary to previous hypotheses claiming for an innate right-hemispheric bias for processing prosodic information, at 7 years of age the low-frequency components of speech are processed in a bilateral manner. Lastly, delta speech-brain entrainment in the right hemisphere was related to an indirect measure of intelligibility, providing preliminary evidence that the entrainment phenomenon might support core linguistic operations since early childhood. © 2020 The Authors. Developmental Science published by John Wiley & Sons Ltd.The development of the neuromuscular junction depends on signaling processes that involve protein phosphorylation. Motor neuron releases agrin to activate muscle protein Dok-7, a key tyrosine kinase essential for the formation of a mature and functional neuromuscular junction. However, the signaling cascade downstream of Dok-7 remains poorly understoo

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