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https://www.selleckchem.com/products/pha-767491.html [Formula see text] is the first successfully synthesized salt that has a polymeric nitrogen moeity ([Formula see text]). Although 12 other [Formula see text] salts followed, with [Formula see text] and [Formula see text] being the most stable, the crystal structure of [Formula see text] remains unknown. Currently, it is impossible to experimentally determine the structures of [Formula see text] due to its marginal stability and explosive nature. Here, following an ab initio evolutionary prediction and using only the stoichiometry of [Formula see text] as a starting point, we were able to reveal the crystal structure of this high energy density material (HEDM). The [Formula see text] symmetry of the [Formula see text] cation, as suggested from earlier investigations, is confirmed to be the symmetry adopted by this polymeric nitrogen within the crystal. This result gave full confidence in the validity of this crystal prediction approach. While stability of the [Formula see text] within the crystal is found to be driven by electronic considerations, the marginal stability of this HEDM is found to be related to a partial softening of its phonon modes.Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and of splice factor kinases that regulate splice factor activity. Recently the CDC2-like kinases (CLKs) have attracted attention due to their increasing involvement in cancer. We measured the effect of the CLK inhibitor, the benzothiazole TG003, on two prostate cancer cell lines. TG003 reduced cell proliferation and increased apoptosis in PC3 and DU145 cells. Conversely, the overexpression of CLK1 in PC3 cells prevented TG003 from reducing cell proliferation. TG003 slowed scratch closure and reduced cell migration and invasion in

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