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https://www.selleckchem.com/products/protac-tubulin-degrader-1.html The inherent plasticity of clinically evolving cancer justifies approaches to characterize and prevent undesirable activation of early oncogenic pathways. CONCLUSIONS Study of the pattern of intracellular signal pathway activation by anticancer drugs can lead to development of efficient treatment strategies by reducing detrimental secondary effects. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Despite of many successes in discovery of numerous cancer chemotherapeutic agents from natural sources, some of the moieties were dropped because of its inefficiency or serious toxicity. Mitosis is an ordered series of fundamentally mechanical events in which identical copies of the genome are moved to two discrete locations within the dividing cell. The crucial role of the mitotic spindle in cell division has identified which is an important target in cancer chemotherapy. In the present study we are reporting molecular docking studies and in silico pharmacokinetic profile of selected phytoconstituents obtained from Amyris pinnata. METHODS Molecular docking studies of selected phytoconstituents were performed using iGEMDOCK. The crystal structure of protein was exported from protein data bank (PDB id 4C4H). In silico pharmacokinetic profile of selected phytoconstituents were performed using SWISSADME server. RESULTS Compound AMNP6 showed higher binding affinity as compared to standard ligand. All the selected phytoconstituents has passed Lipinski rule of five and shown no violations. CONCLUSION Good binding affinity and drug likeliness of the AMNP6 suggest that it can be further investigated and explored as mitotic spindle kinase inhibitor in cancer disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Activation of Nrf2/HO-1 pathway has been shown to protect against cisplatin-induced nep

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