80 (95 % confidence interval (CI) 0.72-0.87) versus 0.78 (95 % CI 0.69-0.86) for bpMRI (p = 0.52) and for SVI, mpMRI AUC was 0.91 (95 % CI 0.84-0.96) versus 0.86 (95 % CI 0.78-0.92) for bpMRI (p = 0.02), respectively. Inter-reader agreement for both ECE and SVI prediction was substantial, with a marginally higher k-value for mpMRI (k range, 0.67-0.75) than bpMRI (k range, 0.65-0.69). Diagnostic performance of bpMRI and mpMRI was comparable for detection of ECE, however, mpMRI with contrast was superior for SVI detection and improved the inter-reader agreement. Diagnostic performance of bpMRI and mpMRI was comparable for detection of ECE, however, mpMRI with contrast was superior for SVI detection and improved the inter-reader agreement. To investigate the predictive performance of the maximum standardized uptake value (SUV ) and mean standardized uptake value (SUV ) of primary lesions based on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT) for EGFR mutation status in patients with non-small cell lung cancer (NSCLC). The PubMed/Medline, Embase, Cochrane Library and Web of Science databases were searched as of January 1, 2021. Studies whose reported data could be used to construct contingency tables were included. Study characteristics were extracted, and methodological quality assessment was conducted by two separate reviewers using the Quality Assessment of Diagnostic Accuracy Studies. The pooled sensitivity, specificity and area under the summary receiver operating characteristic curve (AUROC) were calculated. The possible causes of heterogeneity were analysed by meta-regression. The 18 included studies had a total of 4024 patients. The majority of the studies showed a low to unclear risk of bias and concerns of applicability. For differentiating EGFR-mutant NSCLC from wild-type NSCLC, the pooled sensitivity and specificity were 71 % and 60 % for SUV and 64 % and 63 % for SUV , respectively. The summary AUROCs of SUV and SUV were 0.69 (95 % CI, 0.65-0.73) and 0.68 (95 % CI, 0.64-0.72), respectively. The meta-regression analysis indicated that blindness to EGFR mutation test results, the number of readers and the number of PET/CT scanners were possible causes of heterogeneity. Our meta-analysis implied that SUV and SUV of primary lesions from F-FDG PET/CT harboured moderate predictive efficacy for the EGFR mutation status of NSCLC. Our meta-analysis implied that SUVmax and SUVmean of primary lesions from 18F-FDG PET/CT harboured moderate predictive efficacy for the EGFR mutation status of NSCLC. To investigate whether prostate cancer (PCa) lesions regarding histopathological composition exhibit different morphological features on multiparametric prostate MRI (mpMRI). We investigated men with PCa with available mpMRI and whole-mount specimens between June 2015 to December 2020.The acquisition protocol consistent with the Prostate Imaging Reporting and Data System (PI-RADS). Two observers evaluated the images following the PI-RADS v2.1. guideline before biopsy and radical prostatectomy. The discrepancies were resolved in a joint meeting. A genitourinary pathologist reviewed the whole-digitalized mount specimens, and the lesions with Gleason score of 7 and above (3 + 4 and above), and/or cancers with a maximum diameter of 6 mm and more, and/or extraprostatic extension were accepted as clinically significant PCa. The PI-RADS scores and the diameter of the clinically significant PCa on mpMRI concerning histopathological components (i.e., cribriform component, intraductal pattern, or without cribriformficance, clinically significant PCa with the cribriform component and without any intraductal or cribriform component are more likely to manifests mpMRI invisible foci than the intraductal pattern. Further multi-center studies are warranted to precisely elucidate mpMRI features of PCa regarding histopathological composition. Greenspace exposures are often measured using single exposure metrics, which can lead to conflicting results. Existing methodologies are limited in their ability to estimate greenspace exposure comprehensively. https://www.selleckchem.com/products/reparixin-repertaxin.html We demonstrate new methods for estimating single and combined greenspace exposure metrics, representing multiple exposure types that combine impacts at various scales. We also investigate the association between those greenspace exposure types and premature mortality. We used geospatial data and spatial analytics to model and map greenspace availability, accessibility and eye-level visibility exposure metrics. These were harmonised and standardised to create a novel composite greenspace exposure index (CGEI). Using these metrics, we investigated associations between greenspace exposures and years of potential life lost (YPLL) for 1673 neighbourhoods applying spatial autoregressive models. We also investigated the variations in these associations in conjunction with levels of socioeconomic deprivatiowed that a higher composite greenspace exposure is associated with lower premature mortality. Our methods and metrics provide a novel approach to the assessment of multiple greenspace exposure types, and can be linked to the broader exposome framework. Our results showed that a higher composite greenspace exposure is associated with lower premature mortality.Due to the presence of trace element (TE) in agricultural soils, wide areas are unproper for food production and the clean-up of soil is not a feasible option. Considering the potential remediation options, the use of aromatic plants producing a high quantity of biomass and developing high-added value sectors such as essential oil (EO) production could be valuable regarding one of the phytomanagement objectives, i.e. the restoration of an economic activity. The purpose of this study was hence to evaluate in situ the suitability of two aromatic crops, clary sage and coriander, for the phytomanagement of aged TE-polluted soils, taking into account plants' growth, development and biomass production, essential oil (EO) content and quality as well as a techno-economic feasibility analysis of the channel. In situ experiments have been carried out on two agricultural plots of 1.5 ha, a TE-polluted one (Pb 394 ppm - Zn 443 ppm - Cd 7.2 ppm) and an unpolluted one (Pb 22 ppm - Zn 48 ppm - Cd 0.4 ppm). Our findings have shown the ability of coriander and sage to grow similarly on both unpolluted and TE-polluted soil and to produce significant amounts of biomass.