https://www.selleckchem.com/products/gsk1838705a.html Additionally, the TE domains preferentially cyclized polyketides that bore the expected oxidation state at the C-3 position, effectively bypassing non-cognate module directed reduction and altering the predicted catalytic sequence. Extending these findings led to formation of a novel metabolite containing a pyran ring instead of the predicted macrolactone. Collectively, these data provide new insights regarding the PKS TE as an important target for protein engineering to optimize polyketide analog assembly in engineered PKS pathways. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Patients with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus are at risk for acute kidney injury (AKI). Requirements of kidney replacement therapies (KRT) may be particularly intense for kidney transplant recipients with COVID-19 who develop AKI, due to their chronic use of steroids (1) and theoretically higher viral loads (2) that may lead to a catabolic state (3). Herein, we report the case of a kidney transplant recipient with COVID-19 infection, AKI, and a high catabolic state evidenced by refractory hyperkalemia and azotemia. This article is protected by copyright. All rights reserved.AIMS Red yeast rice (RYR), produced by inoculating Monascus strains to steamed rice, contains many kinds of physiologically bioactive compounds, among which monacolin K can be used as an antihypercholesterolemic agent. However, RYR can be polluted by the mycotoxin citrinin, which has nephrotoxic and hepatotoxic activities. To avoid the risk of citrinin contamination in Monascus fermented products, it is important to screen for Monascus strains that produce no or low citrinin. METHODS AND RESULTS Five autochthonous Monascus strains with high yield monacolin K and undetectable citrinin were obtained by using high performance liquid chromatography (HPLC). All five strains were identified