istered December 01, 2017.
 Netherlands Trial Registry Identifier NTR6702. Date registered December 01, 2017.
  Social and cultural norms, operating through social networks, may influence an individual's dietary choices. We examined correlations between social network characteristics and dietary patterns among South Asians in the United States (U.S.).
 
  Data from the Mediators of Atherosclerosis in South Asians Living in America(MASALA) Social Network study were analyzed among 756 participants (mean age = 59 y standard deviation [SD] = 9 y; 44% women). A culturally adapted, validated food frequency questionnaire was used for dietary assessment. A posteriori dietary patterns using principal component analysis were named 1) animal protein, 2) fried snacks, sweets and high-fat dairy, and 3) fruits, vegetables, nuts and legumes. Social network characteristics were assessed using a standard egocentric approach, where participants (egos) self-reported data on perceived dietary habits of their network members. Partial correlations between social network characteristics and egos' dietary patterns were examined.
 
  The mean soention studies among South Asians should consider social network characteristics as candidate components for dietary intervention.
  The anticoagulant edoxaban is used clinically at doses of 30-60 mg/day; however, we experienced a patient who had taken an overdose of edoxaban of 750 mg. We investigated the pharmacokinetics of edoxaban in this patient by using liquid chromatography-tandem spectrometry to estimate the follow-up period in emergency clinical practice with this medicine.
 
  The patient was a 57-year-old woman (body weight, 69 kg) who had taken a single oral dose of 750 mg of edoxaban in a suicide attempt.  https://www.selleckchem.com/products/Masitinib-(AB1010).html  She was emergently admitted to Kyoto Medical Center. The patient's edoxaban plasma concentrations during ambulance transport (8 h after oral administration) were ~ 4900 ng/ml, and the concentration gradually decreased to ~ 10 ng/mL and to detectable but unmeasurable levels of ~ 1.0 ng/mL at 60 h and 100 h, respectively. The linear range of the relationship between the dose and plasma concentration was assumed to have been exceeded during the first 8 h; however, the measured elimination rate of edoxaban was similar to that visodel previously established for edoxaban to predict the pharmacokinetics in the current case. It is hoped that the results of this study, which encompass drug monitoring data in the patient and visualized pharmacokinetic prediction, will serve as an index when setting the treatment and follow-up period in cases of drug overdose for medicines such as edoxaban in emergency clinical practice.The breadth of children's attentional field around their mother determines whether securely or insecurely attached children are at risk to develop depressive symptoms when confronted with distress in adolescence. To test this effect longitudinally, we measured children's (M age = 10.93; N = 109) baseline attentional breadth around their mother, attachment status (combining attachment coherence, secure base script knowledge, and self-reported trust), and self-reported depressive symptoms. One and two years later, we measured self-reported distress and depressive symptoms. We tested three-way interactions between attentional breadth × attachment × distress on changes in depressive symptoms. This three-way interaction was marginally significantly linked with changes in depressive symptoms from baseline to year 1, and significantly with changes in depressive symptoms from baseline to year 2. Results pointed to the protective role of a narrow attentional field around the mother in middle childhood for securely attached children who are confronted with distress later in life.Numerous studies have shown a consistent relationship between verbal working memory (WM) and native-language as well as non-native language learning abilities. However, the role of attentional abilities has been rarely explored, although these abilities have been shown to be associated both with verbal working memory and oral language proficiency. This study investigated the association between WM, attention and language proficiency in young adults raised with three different languages (Luxembourgish, German and French). Auditory-verbal WM abilities were assessed via an immediate serial recall task. Attentional abilities were assessed via auditory-verbal and visuo-spatial attentional tasks. Using a Bayesian correlational approach, we observed robust evidence for an association between auditory-verbal WM abilities and non-native language proficiency. At the same time, we observed no reliable evidence in favor of an association between language proficiency and auditory-verbal/visuo-spatial attentional measures. These results suggest that auditory-verbal WM and non-native language proficiency are strongly linked in young multilingual adults, irrespective of auditory-verbal or visuo-spatial attentional abilities.
  The purpose of this study was to examine the association of lean body mass (LBM) to the development of vasomotor symptoms (VMS) as women transition through menopause.
 
  This study is a secondary use of data available for public use from follow up visits six through 10 for participants in the Study of Women's Health Across the Nation. The study examined 2533 women, between the ages 42-52 years, each year over a10-year period. Data was modeled for associations of lean body mass and VMS. Changes in LBM since prior visit and since baseline were also modeled along with differences in means using binary logistic regression, adjusting for covariates.
 
  LBM was significantly associated to concurrent VMS (
   = .036), percent change in LBM since prior visit (
   = .003), percent change since baseline (
   < .001), and overall means associations (
   = .023). LBM was not significant for VMS at individual visit measures. In mixed regression modeling, time was significant (
   < .0001) at all visits. The estimated probability of developing VMS decreases significantly as LBM increases.
 
  Lean body mass is negatively associated with incident VMS. Our data suggests that maintaining higher levels of LBM during the menopausal transition may be protective against the development of VMS. Every woman will experience menopause in her life and the ability to potentially prevent the onset of specific symptoms through basic interventions, such as resistance training to increase lean body mass, may positively impact this large population.
 Lean body mass is negatively associated with incident VMS. Our data suggests that maintaining higher levels of LBM during the menopausal transition may be protective against the development of VMS. Every woman will experience menopause in her life and the ability to potentially prevent the onset of specific symptoms through basic interventions, such as resistance training to increase lean body mass, may positively impact this large population.