Grading of DD by CMR agreed with that by echocardiography in 43 of 46 cases (93%), of which 9% were normal, 2% indeterminate, 63% grade 1 DD, 4% grade 2 DD, and 15% grade 3 DD. There was a very good categorical agreement, with a weighted Cohen kappa coefficient of 0.857 (95% confidence interval 0.73 to 1.00; p<0.001).
 
  A comprehensive CMR protocol for grading DD encompassing diastolic blood and myocardial velocities, estimated pulmonary artery pressure, and left atrial volume showed very good agreement with echocardiography.
 A comprehensive CMR protocol for grading DD encompassing diastolic blood and myocardial velocities, estimated pulmonary artery pressure, and left atrial volume showed very good agreement with echocardiography.
  The purpose of this study was to investigate the prognostic implications of the ratio of mitral regurgitant volume (RVol) to left ventricular (LV) end-diastolic volume (EDV) in patients with significant secondary mitral regurgitation (MR).
 
  Quantification of secondary MR remains challenging, and its severity can be over- or underestimated when using the proximal isovelocity surface area method, which does not take LV volume into account. This limitation can be addressed by normalizing mitral RVol to LVEDV.
 
  A total of 379 patients (mean age 67 ± 11 years; 63% male) with significant (moderate and severe) secondary MR were divided into 2 groups according to the RVol/EDV ratio RVol/EDV≥20% (greater MR/smaller EDV) and<20% (smaller MR/larger EDV). The primary endpoint was all-cause mortality.
 
  During median (interquartile range) follow-up of 50 (26 to 94) months, 199 (52.5%) patients died. When considering patients receiving medical therapy only, patients with RVol/EDV ratio≥20% tended to have higher mort/EDV ratio was independently associated with reduced all-cause mortality. when mitral valve interventions were taken into consideration.
  This study sought to define the 2-dimensional and Doppler echocardiographic hemodynamics associated with each Society for Cardiovascular Angiography and Interventions (SCAI) stage, and to determine their association with mortality.
 
  The SCAI shock stages classification stratifies mortality risk in cardiac intensive care unit (CICU) patients, but the echocardiographic and hemodynamic parameters that define these SCAI shock stages are unknown.
 
  Unique CICU patients admitted from 2007 to 2015 who had a transthoracic echocardiogram within 1day of CICU admission were included. Echocardiographic variables were evaluated as a function of SCAI shock stage. Multivariable logistic regression determined the association between echocardiographic parameters with adjusted hospital mortality.
 
  We included 5,453 patients with a median age of 69.3 years (interquartile range 58.2 to 79.0 years) (37% women), and a median left ventricular ejection fraction (LVEF) of 50% (interquartile range 35% to 61%). Higher SCAI shock st with the SCAI shock stages and improve risk stratification for hospital mortality in CICU patients. Low stroke volume index and high E/e' ratio demonstrated the strongest association with hospital mortality.
  The aims of this study were to test the magnitude of agreement between echocardiography (echo)- and cardiac magnetic resonance (CMR)-derived left atrial (LA) strain and to study their relative diagnostic performance in discriminating diastolic dysfunction (DD) and predicting atrial fibrillation (AF).
 
  Peak atrial longitudinal strain (PALS) is a novel performance index. Utility of echo-quantified LA strain has yet to be prospectively tested in relation to current DD guidelines or compared to CMR.
 
  The study population comprised 257 post-myocardial infarction (MI) patients undergoing echo and CMR, including prospective derivation (n=157) and clinical validation (n=100) cohorts. DD was graded on echo using established consensus guidelines blinded to strain results.
 
  PALS on both echo and CMR was nearly 2-fold lower among patients with versus no DD (p<0.001) and was significantly different in those with mild versus no DD (p<0.01). In contrast, LA geometric parameters including echo- and CMR-derived volof DD, and improves prediction of AF and congestive heart failure after MI.
 Echo-derived PALS parallels results of CMR, yields incremental diagnostic utility versus LA geometry for stratifying presence and severity of DD, and improves prediction of AF and congestive heart failure after MI.
  This study sought to explore sex-based differences in total and compositional plaque volume (PV) progression.
 
  It is unclear whether sex has an impact on PV progression in patients with coronary artery disease (CAD).
 
  The study analyzed a prospective multinational registry of consecutive patients with suspected CAD who underwent 2 or more clinically indicated coronary computed tomography angiography (CTA) at≥2-year intervals. Total and compositional PV at baseline and follow-up were quantitatively analyzed and normalized using the analyzed total vessel length. Multivariate linear regression models were constructed.
 
  Of the 1,255 patients included (median coronary CTA interval 3.8 years), 543 were women and 712 were men. Women were older (62 ± 9 years of age vs. 59 ± 9 years of age; p<0.001) and had higher total cholesterol levels (195 ± 41mg/dl vs. 187 ± 39mg/dl; p=0.002). Prevalence of hypertension, diabetes, and family history of CAD were not different (all p > 0.05). At baseline, men possessed gsk stratification according to sex. (NCT02803411).Pumping devices with the electrokinetics phenomena are important in many microscale transport phenomena in physiology. This study presents a theoretical and numerical investigation on the peristaltic pumping of non-Newtonian Sutterby nanofluid through capillary in presence of electromagnetohydrodynamics. Here blood (Sutterby fluid) is taken as a base fluid and nanofluid is prepared by the suspension of graphene oxide nanoparticle in blood. Graphene oxide is extremely useful in the medical domain for drug delivery and cancer treatment.  https://www.selleckchem.com/products/reacp53.html  The modified Buongiorno model for nanofluids and Poisson-Boltzmann ionic distribution is adopted for the formulation of the present problem. Constitutive flow equations are linearized by the implementation of approximations low Reynolds number, large wavelength, and the Debye-Hückel linearization. The numerical solution of reduced coupled and nonlinear set of equations is computed through Mathematica and graphical illustration is presented. Further, the impacts of buoyancy forces, thermal radiation, and mixed convection are also studied.