After the introduction of hepatitis B (HB) vaccination in 1995 in newborns, two catch-up campaigns targeted unvaccinated 9year old in 2000-2003 (born 1991-1994) and the 18year old in 2004-2008 (born 1986-1990), resulting in several birth-cohorts. Our objective was to assess the anti-HBs titers in each birth-cohort.
 
  We included all outpatients (78.5%) and hospitalized patients with measured anti-HBs antibody titers in the Teaching Hospital of Infectious Diseases, Cluj-Napoca, Romania, during April 2014 - December 2018 (without HB history). We compared the anti-HBs titers in all birth-cohorts using the Lexis surfaces (titers by age, time period and cohort patterns). We also evaluated the number of acute HB in the corresponding inpatient birth-cohorts and special groups.
 
  We included 2963 participants, mean age=31.0±14.2, 64.1% women. The birth-cohort 1995-2006, vaccinated after delivery (n=424, 3-dose HB vaccine coverage>90%), had significantly lower protective titers (41.3% >10 mIU/mL) compared to ts following the primary immunization and a booster seems unsupported. Further studies should be done to assess the need of a booster dose within the general population and special groups.Dual antiplatelet therapy (DAPT) reduces ischemic and thrombotic events after percutaneous coronary intervention (PCI). Initial reports of higher myocardial infarction and mortality rates prompted guideline committees to choose 12-month duration of DAPT after PCI. However, higher bleeding rates with DAPT remain a major concern. Since these guidelines were published, there have been improvements in stent design, deployment techniques, and antiplatelet therapies, which have reduced ischemic events. To address bleeding concerns, trials were performed to evaluate the effectiveness of short-duration DAPT. Two main strategies were employed (1) aspirin monotherapy after a short-duration DAPT, and (2) P2Y12 inhibitor monotherapy after a short-duration DAPT. In this review, we outline all the major trials on short-duration DAPT that have examined the previously mentioned strategies and propose a new individualized treatment algorithm for which monotherapy to choose or remove after PCI. In conclusion, while removing the P2Y12 inhibitor after a short DAPT appears to be safe in the low-risk population, removing aspirin and continuing the P2Y12 inhibitor as monotherapy would be the preferred strategy in intermediate- to high-risk patients to mitigate the bleeding risk.Cardio-oncology has recently been developed to prevent, identify and manage cardiovascular events in patients with cancer receiving cardiotoxic chemotherapy. Among cardiovascular complications of cancer therapy, myocardial dysfunction and heart failure are one of the most concerning issue. Since cardiotoxicity adversely affect quality of life and prognosis in cancer patients, its prevention, detection and treatment are crucial. This review aimed to describe the main chemotherapies able to induce myocardial dysfunction and to emphazise the pivotal role of echocardiography in the follow up. We also intent to provide to the lector a better understanding of what to do in case of cardiotoxicity.
  Our work aimed to identify the key differentially expressed circular RNAs (circRNAs) (DECs) in non-small cell lung cancer (NSCLC).
 
  An integrated analysis based on public NSCLC datasets obtained from Gene Expression Omnibus was performed. DECs in NSCLC were subsequently identified. Bioinformatics analyses were utilized for describing the predictable functions of DECs including circRNA-miRNA network construction and pathway enrichment. The diagnostic value of candidate DECs among NSCLC and healthy individuals were preliminarily evaluated in GSE101586, GSEE101684, GSE112214 datasets.
 
  A total of 43 up-regulated and 78 down-regulated DECs in NSCLC were identified. The mTOR signaling pathway, ErbB signaling pathway and cell cycle were significantly enriched from the originated genes of DECs in NSCLC. In the circRNA-miRNA network, hsa-circ-0002702, hsa-circ-0049271, hsa-circ-0009150 and hsa-circ-0053958 had high connectivity with miRNAs, which respectively interacted with 122, 42, 41, and 39 miRNAs. hsa_circ_0003028, hsa_circ_0015278, hsa_circ_0043256, hsa_circ_0049657 and hsa_circ_0074930 could distinguish NSCLC patients from healthy individuals in GSE101586, GSEE101684, GSE112214 datasets.
 
  DECs including hsa_circ_0003028, hsa_circ_0015278, hsa_circ_0043256, hsa_circ_0049657 and hsa_circ_0074930 had diagnostic value in NSCLC. These DECs might play key roles in NSCLC pathogenesis through the mTOR signaling pathway, ErbB signaling pathway and cell cycle.
 DECs including hsa_circ_0003028, hsa_circ_0015278, hsa_circ_0043256, hsa_circ_0049657 and hsa_circ_0074930 had diagnostic value in NSCLC. These DECs might play key roles in NSCLC pathogenesis through the mTOR signaling pathway, ErbB signaling pathway and cell cycle.Objective This study analysed screening for COVID-19 before surgery and outcomes of any perioperative testing for SARS-CoV-2 infection during pandemic-restricted surgery. Methods An audit was conducted with routinely collected health data before both elective and non-elective surgery at two large Melbourne hospitals during April and early May 2020. We looked for documented systematic screening for COVID-19 disease and fever (>38°C) and results of SARS-COV-2 testing, and proposed a minimum acceptable documenting rate of 85%.  https://www.selleckchem.com/products/tegatrabetan.html  Results The study included 2197 consecutive patients (1279 (58%) undergoing elective surgery, 917 (42%) undergoing non-elective surgery) across most specialities. Although 926 (72%) patients undergoing elective surgery had both systematic screening and temperature documented, approximately half that percentage undergoing non-elective surgery (n=347; 38%) had both documented. However, 871 (95%) of non-elective surgery patients had temperature documented. Acknowledging limited screening, 85 ractitioners? Clear documenting is important in managing patients. Pandemics and other crises can require rapid changes in practice. Implementing such measures may be less complete than anticipated and may require greater use of evidence-based implementation strategies, particularly in the less predictable care of non-elective surgery patients.