https://www.selleckchem.com/products/NVP-AUY922.html Conclusions This study extends our knowledge of NP occurrence and development and provides new therapeutic targets for future NP treatment.Introduction Carotid artery stenting (CAS) via a trans-carotid revascularization (TCAR) approach has emerged as an alternative when carotid endarterectomy or conventional CAS is contraindicated. The present study was conducted to assess the feasibility and safety of TCAR in patients with carotid artery stenosis. Evidence acquisition A systematic review of the literature was performed, according to PRISMA guidelines (Preferred Reporting Items for Systematic reviews and Meta- Analyses), using PubMed, EMBASE and CENTRAL databases. The primary outcomes included technical success, perioperative neurological event, myocardial ischemic events, death and their composite. Operational duration, flow reversal time and any local procedure related complication (carotid dissection and cranial nerve injury) were also recorded. Evidence synthesis Twenty three studies were included, reporting on 3.130 patients, undergoing TCAR. Thirty-five per cent of them were symptomatic. Technical success was 98% (95% CI 0.97-0.99; p=0.11,ld be considered an acceptable alternative for patients treated for carotid artery stenosis.Background The present study aimed to investigate the effects of HIIT versus moderate-intensity continuous training (MICT) on blood pressure (BP) and parameters of arterial stiffness in young athletes. Methods 17 rowers (aged 16±1.4 years) were randomized into an intervention group (IG) (n=10) and the control group (CG) (n=7). During an 8-week intervention period, the IG completed a HIIT on the rowing ergometer twice weekly (2x4x2 min at ≈95% of maximum heart rate (HRmax), 60-sec rest) in addition to the regular rowing training (3x/week MICT 70-90min, ≈70% HRmax). The CG completed the regular normal rowing training and, instead of the HIIT units, two additional MICT units (70-90min,