A multiplicatively normalized intuitionistic fuzzy decision matrix is established from the interval-value-based assessments of alternatives and a method is proposed to determine the intuitionistic fuzzy value based comprehensive scores of alternatives. A case study is offered to illustrate how to build a performance evaluation index system of low-carbon tourism scenic spots located at Zhejiang Province of China and show the use of the proposed intuitionistic fuzzy hierarchical MCDM method.The autosomal dominant chondrodystrophies, the Stickler type 2 and Marshall syndromes, are characterized by facial abnormalities, vision deficits, hearing loss, and articular joint issues resulting from mutations in COL11A1. Zebrafish carry two copies of the Col11a1 gene, designated Col11a1a and Col11a1b. Col11a1a is located on zebrafish chromosome 24 and Col11a1b is located on zebrafish chromosome 2. Expression patterns are distinct for Col11a1a and Col11a1b and Col11a1a is most similar to COL11A1 that is responsible for human autosomal chondrodystrophies and the gene responsible for changes in the chondrodystrophic mouse model cho/cho. We investigated the function of Col11a1a in craniofacial and axial skeletal development in zebrafish using a knockdown approach. Knockdown revealed abnormalities in Meckel's cartilage, the otoliths, and overall body length.  https://www.selleckchem.com/products/VX-770.html  Similar phenotypes were observed using a CRISPR/Cas9 gene-editing approach, although the CRISPR/Cas9 effect was more severe compared to the transient effect of the antisense morpholino oligonucleotide treatment. The results of this study provide evidence that the zebrafish gene for Col11a1a is required for normal development and has similar functions to the mammalian COL11A1 gene. Due to its transparency, external fertilization, the Col11a1a knockdown, and knockout zebrafish model systems can, therefore, contribute to filling the gap in knowledge about early events during vertebrate skeletal development that are not as tenable in mammalian model systems and help us understand Col11a1-related early developmental events.
  computer-based screenings are usually used for early detection of a child's mental development problems. However, there are no such screenings in Russia yet. This study aimed to elaborate scales for rapid monitoring of mental development of 3-year-olds.
 
  863 children took part in the study, among them 814 children of the group Norm, 49 children with developmental delay (DD), including 23 children with symptoms of autistic spectrum disorder (ASD). The multifactor study of mental development tool was used as a part of a software complex for longitudinal research for data collection. This study used a set of 233 tasks that were adequate for 3-year-olds. Exploratory and confirmatory factor analysis was used for the elaboration and factor validation of the scales. The structure of the relationship between scales and age was refined using structural equation modeling.
 
  as a result of the research, screening scales were elaborated "Logical reasoning", "Motor skills", "General awareness", "Executive functions". T system for wide application.
  The effect of obesity in early adulthood and weight loss on incident hypertension in older age has not been well characterized. This study aimed to examine the association of weight loss from young adulthood to midlife with risk of incident hypertension later in life.
 
  We performed a retrospective cohort study using data from the National Health and Nutrition Examination Survey (NHANES). Five weight change groups were categorized stable normal, weight loss, weight gain, maximum overweight and stable obese. The hazard ratios (HRs) and 95% confidence intervals (CIs) of the association between weight change and risk of hypertension in later life were estimated using Cox regression models.
 
  Compared with participants who maintained normal weight, the stable obese, weight gain, maximum overweight and weight loss groups exhibited significantly higher risks of incident hypertension, with HR of 3.28 (95% CI = 2.71 to 3.96), 2.93 (95% CI = 2.62 to 3.28), 1.76 (95% CI = 1.55 to 2.00) and 1.97 (95% CI = 1.17 to 3.31), respectively. We also observed a lower risk among those in the weight loss group (HR = 0.60, 95% CI = 0.35 to 1.02) compared with those who were stable obese.
 
  Weight loss from early to middle adulthood was associated with lower risk of incident hypertension as compared to those who stayed obese and higher risk of incident hypertension as compared to those who maintained normal weight. Thus, maintaining normal weight throughout adulthood may be important for the primary prevention of hypertension.
 Weight loss from early to middle adulthood was associated with lower risk of incident hypertension as compared to those who stayed obese and higher risk of incident hypertension as compared to those who maintained normal weight. Thus, maintaining normal weight throughout adulthood may be important for the primary prevention of hypertension.The aim of this study was to analyze the influence of the match half and the playing position on physical requirements in the Spanish Professional Futsal League players during official games. The external load from distance, speed, acceleration and deceleration variables were obtained from fourteen elite futsal players during 10 official matches of the 2019-2020 season using a Local Positioning System with ultra-wideband technology installed on the futsal pitch. The results revealed similar results from physical requirements between first and second half (p > 0.05). Wingers demonstrated greater high-speed running distance (+4.04 m·min-1; CI95% 0.35 to 7.72; ES 0.87) than pivots (p > 0.05). There were a high number of accelerations (7.42-9.41 n·min-1) and decelerations (7.37-9.12 n·min-1) per minute in all player positions. The principal finding of the current manuscript did not evidence differences in the physical performance of players between the first and second half. The physical requirements varied among pivots and wingers regarding high-intensity actions. These outcomes add new contributions to the understanding of futsal physical demands.