https://www.selleckchem.com/products/mrt67307.html Candidatus Accumulibacter phosphatis is an important microorganism for enhanced biological phosphorus removal (EBPR). In a previous study, we found a remarkable flexibility regarding salinity, since this same microorganism could thrive in both freshwater- and seawater-based environments, but the mechanism for the tolerance to saline conditions remained unknown. Here, we identified and described the role of trehalose as an osmolyte in Ca. Accumulibacter phosphatis. A freshwater-adapted culture was exposed to a single batch cycle of hyperosmotic and hypo-osmotic shock, which led to the release of trehalose up to 5.34 mg trehalose/g volatile suspended solids (VSS). Long-term adaptation to 30% seawater-based medium in a sequencing batch reactor (SBR) gave a stable operation with complete anaerobic uptake of acetate and propionate along with phosphate release of 0.73 Pmol/Cmol, and complete aerobic uptake of phosphate. Microbial analysis showed Ca. Accumulibacter phosphatis clade I as the dominant organism in bothr phosphatis can convert glycogen into trehalose. • Ca. Accumulibacter phosphatis clade I is present and active in both seawater and freshwater.Dietary fiber has beneficial effects on obesity-related diseases and gut microbiota, contributing a key role in the interaction between dietary metabolism and host metabolism. Our objective was to investigate the cause of the improvement in multiple types of physiological states with seaweed Undaria pinnatifida treatment on high-fat diet-fed mice and to evaluate whether its consequent anti-adiposity and anti-hyperlipidemic effects are associated with gut microbiota and its metabolomics regulation. U. pinnatifida administration in our experiment was shown to significantly decrease high-fat diet-induced body weight gain, as well as epididymal and abdominal adiposity. U. pinnatifida intake also significantly reduced liver weight and serum triacylglycerol accumulation. We al