Exosomes are endogenous vesicles of cells, and can be used as important biomarkers for cancers. In this work, we developed a sensitive and reliable SERS sensor for simultaneous detection of multiple cancer-related exosomes. The SERS detection probes were made of bimetallic SERS-active nanotags, gold-silver-silver core-shell-shell nanotrepangs (GSSNTs), which were composed of bumpy surface nanorod (gold nanotrepang, GNT) cores and bilayer silver shells, and decorated with linker DNAs, which were complementary to the aptamer targeting exosomes. Three kinds of SERS detection probes were designed via the adoption of different Raman reporter molecules and linker DNAs. The capture probes were prepared by modifying specific aptamers of the target exosomes on magnetic beads (MBs). In the absence of target exosomes, SERS detection probes were coupled with MBs via specific DNA hybridization for use as aptamer-based SERS sensors. In the presence of target exosomes, the aptamer specifically recognized and captured the exosomes, and GSSNTs were subsequently released into the supernatant. Therefore, attenuated SERS signals were detected on the MBs, indicating the presence of target exosomes. The proposed aptamer-based SERS sensor is expected to be a facile and sensitive method for the multiplex detection of cancer biomarkers and has potential future applications in clinical diagnosis.Methicillin-resistant Staphylococcus aureus (MRSA) is considered to be one of the important hospital-acquired pathogens. MRSA is also commonly associated with hospital-acquired infections and mortality. Quantitative and precise detection of MRSA is essential for rapid diagnosis and subsequent effective disease management strategies. We herein developed a highly specific method for rapid MRSA detection that combines surface-enhanced Raman spectroscopy (SERS) nanotags and polymerase chain reaction (PCR). SERS provided the sensitivity and spectral multiplexing capability while PCR provided the specificity required for the assay. The method was tested by the simultaneous detection of two MRSA specific genes (mecA and femA) amplified from genomic DNA isolated from clinical specimens. Magnetic isolation and rapid duplex detection were performed to obtain a detectable signal down to 104 input copies within 80 min. This demonstrated the potential of the SERS-PCR based approach for the accurate identification of MRSA at an early-diagnosis stage. This study also provides an alternative approach to the existing methods for detecting clinical targets without compromising sensitivity and selectivity, and with minimal handling steps. We thus believe that this approach will find a broad application in clinical applications.The post-functionalization of six novel symmetric and asymmetric meso-expanded Co(iii) corroles through Suzuki-Miyaura coupling reactions has been successfully accomplished and is reported along with their structural characterization. An analysis of the structure-property relationships of the optical and redox properties of the corroles has been carried out by comparing their optical spectra and their electrochemical properties. The results demonstrate that post-functionalized meso-expanded Co(iii) triarylcorroles exhibit enhanced electrocatalyzed oxygen reduction reaction (ORR) activity and that their reactivity can be controlled by modulating the electronic structure, the functionalization and the number of coupled meso-substituents.For the first time, hematite (α-Fe2O3) crystals were electrochemically deposited over vertically aligned conductive zinc oxide nanorods (NR) to form a specially designed 3D heterostructure with a unique triple layer structure. The structure formed with a thin layer of ZnFe2O4sandwiched between the hematite and the ZnO, which forms a barrier to reduce the back migration of holes. Hence, the charge separation is significantly improved. The small unequal band gaps of α-Fe2O3and ZnFe2O4help to enhance and broaden visible light absorption. The electron transportation was further improved by yttrium doping in the ZnO (YZnO) NRs, resulting in increased conductivity. This allowed the vertically aligned NRs to perform as electron highways, which also behave as effective optical waveguides for improved light trapping and absorption, since ZnO absorbs little visible light. All these benefits made the unique structures suitable for high performance photoelectrochemical (PEC) water splitting. Optimisation of α-Fe2O3thickness led to a photocurrent density improvement from 0.66 to 0.95 mA cm-2at 1.23 VRHE. This was further improved to 1.59 mA cm-2by annealing at 550°C for 3 hours, representing a record-breaking photocurrent for α-Fe2O3/ZnO systems. Finally IPCE confirmed the successful generation and transfer of photoelectrons under visible light excitation in the specifically designed heterostructure photoanode, with 5% efficiency for blue light, and 15% for violet light. Creative Commons Attribution license.BACKGROUND AND OBJECTIVE Severe cutaneous adverse reactions to drugs (SCARs), have a high morbidity, mortality and present sequelae. Objective To characterize patients with SCARs in eight health care institutions in Latin America.  https://www.selleckchem.com/products/Masitinib-(AB1010).html  METHODS Cross-sectional, descriptive, multicenter, Latin American study of patients diagnosed with SCARs, between January 2009 and December 2018. The analysis was made from a database in BD Clinic. RESULTS Seventy cases were reported. Forty-two (60%) were women. The average age was 38.7 years. Forty-two (60%) had DRESS-DIHS, 12 (17.1%) TEN, 5 (7.1%) SJS, 6 (8.5%) AGEP, 4 (5.7%) other, not classified SCARs, and 1 (1.4%) overlapping TEN/SJS. The main causative drugs were aromatic anticonvulsants in 31 cases (44.3%), beta lactam antibiotics in 11 cases (15.7%) and non-beta lactam antibiotics in 6 cases (8.6%). In all of cases, the suspected drug was withdrawn at the first sign of a SCAR. Sixty-six patients (94.2%) received anti-inflammatory treatment, mostly systemic corticosteroids. Complications occurred in 53 cases (75.7%) and death in three patients (4.3%). Thirteen patients (18.6%) had some type of sequelae. CONCLUSIONS This is the first multicenter report on SCARs in Latin America. DRESS-DIHS was the most frequently reported clinical entity and anticonvulsants were the main triggers. Most of patients received systemic corticosteroids. Complications were frequent and three patients died.