Whether synthetic hibernation will also protect from the deleterious effects of chronic low-dose-rate radiation exposure is currently unknown. Hibernators can modulate their neuronal firing, adjust their cardiovascular function, regulate their body temperature, preserve their muscles during prolonged inactivity, regulate their immune system, and most importantly, increase their radioresistance during the inactive period. According to recent studies, synthetic hibernation, just like natural hibernation, could mitigate radiation-induced toxicity. In this review, we see what artificial hibernation is and how it could help the next generation of astronauts in future interplanetary missions.Healthcare systems worldwide are faced with continuously increasing demand for care, while simultaneously experiencing insufficient capacity and unacceptably long patient waiting times. To improve healthcare access and availability, it is thus necessary to improve capacity utilization and increase the efficiency of existing resource usage. For this, variations in healthcare systems must be managed judiciously, and one solution is to apply a capacity pooling approach. A capacity pool is a general, collaborative capacity that can be allocated to parts of the system where the existing workload and demand for capacity are unusually high. In this study, we investigate how basic mean-variance methodology from portfolio theory can be applied as a capacity pooling approach to healthcare systems.  https://www.selleckchem.com/products/guanosine.html  A numerical example based on fictitious data is used to illustrate the theoretical value of using a portfolio approach in a capacity pooling context. The example shows that there are opportunities to use capacity more efficiently and increase service levels, given the same capacity, and that a mean-variance analysis could be performed to theoretically dimension the most efficient pooling organization. The study concludes with a discussion regarding the practical usefulness of this methodology in the healthcare context.With abundant renewable resources and good biodegradability, bio-based aerogels are considered as promising insulating materials for replacing the conventional petroleum-based foam. In this study, konjac glucomannan (KGM)-based aerogels were prepared as thermal insulation materials via a convenient sol-gel and freeze-drying progress with different content of plant polysaccharides, proteins, and wheat straw. The morphology, thermal conductivity, and flame retardancy of KGM-based aerogels were determined. The KGM-based aerogels showed a uniform three-dimensional porous microstructure. The addition of wheat straw could significantly reduce the pore size of aerogels due to its special multi-cavity structure. KGM-based aerogels showed low densities (0.0234-0.0559 g/cm-3), low thermal conductivities (0.04573-0.05127 W/mK), low peak heat release rate (PHRR, 46.7-165.5 W/g), and low total heat release (THR, 5.7-16.2 kJ/g). Compared to the conventional expanded polystyrene (EPS) and polyurethane (PU) foam, the maximum limiting oxygen index (LOI) of KGM-based aerogels increased by 24.09% and 47.59%, the lowest PHRR decreased by 79.37% and 94.26%, and the lowest THR decreased by 76.54% and 89.25%, respectively. The results demonstrated that the KGM-based aerogels had better performance on flame retardancy than PU and EPS, indicating high potential applications as heat insulation in the green advanced engineering field.From a public health perspective, it is important that children with Down syndrome (DS) lay the foundations of physical activity (PA) early in life to keep active in school, as teenagers and as adults. The aims were to investigate PA patterns in children and adolescents with DS, as well as their parents' and siblings' PA patterns.
  A survey was performed among 310 families with children with DS (54% boys and 46% girls) aged 8-18 years (mean 14.04, SD 3.18) in Sweden. Chi-squared tests and multiple logistic regression were carried out.
 
  Nineteen percent of children and adolescents with DS and 34% of the parents were active three or more times per week. The child's PA level was significantly associated with parents' PA (OR = 5.5), siblings' PA (OR = 5.1) and the child's locomotion ability (OR = 3.5). Physically active parents had active children to a greater extent than inactive parents (59% vs. 29%; 
  < 0.001).
 
  Physically active parents have active children. To promote PA among children and adolescents with DS, it is important to promote and pay attention to the parents' and siblings' PA behavior, as children with DS are dependent on support from the family.
 Physically active parents have active children. To promote PA among children and adolescents with DS, it is important to promote and pay attention to the parents' and siblings' PA behavior, as children with DS are dependent on support from the family.Salinity majorly hinders horizontal and vertical expansion in worldwide wheat production. Productivity can be enhanced using salt-tolerant wheat genotypes. However, the assessment of salt tolerance potential in bread wheat doubled haploid lines (DHL) through agro-physiological traits and stress-related gene expression analysis could potentially minimize the cost of breeding programs and be a powerful way for the selection of the most salt-tolerant genotype. We used an extensive set of agro-physiologic parameters and salt-stress-related gene expressions. Multivariate analysis was used to detect phenotypic and genetic variations of wheat genotypes more closely under salinity stress, and we analyzed how these strategies effectively balance each other. Four doubled haploid lines (DHLs) and the check cultivar (Sakha93) were evaluated in two salinity levels (without and 150 mM NaCl) until harvest. The five genotypes showed reduced growth under 150 mM NaCl; however, the check cultivar (Sakha93) died at the beginning of the flowering stage. Salt stress induced reduction traits, except the canopy temperature and initial electrical conductivity, which was found in each of the five genotypes, with the greatest decline occurring in the check cultivar (Sakha-93) and the least decline in DHL2. The genotypes DHL21 and DHL5 exhibited increased expression rate of salt-stress-related genes (TaNHX1, TaHKT1, and TaCAT1) compared with DHL2 and Sakha93 under salt stress conditions. Principle component analysis detection of the first two components explains 70.78% of the overall variation of all traits (28 out of 32 traits). A multiple linear regression model and path coefficient analysis showed a coefficient of determination (R2) of 0.93. The models identified two interpretive variables, number of spikelets, and/or number of kernels, which can be unbiased traits for assessing wheat DHLs under salinity stress conditions, given their contribution and direct impact on the grain yield.