Previous research has shown that humans are able to acquire statistical regularities among shape parts that form various spatial configurations, via exposure to these configurations without any task or feedback. The present study extends this approach of visual statistical learning to examine whether prior knowledge of parts, acquired in a separate learning context, facilitates acquisition of multi-layer hierarchical representations of objects. After participants had learned to encode a shape-pair as a chunk into memory, they viewed cluttered scenes containing multiple shape chunks. One of the larger configurations was constructed by combining the learned shape-pair with an unfamiliar, complementary shape-pair. Although the complementary shape-pair had never been presented separately during learning, it was remembered better than other shape pairs that were parts of larger configurations. The greater perceived familiarity of the complementary shape-pair depended on the encoding strength of the previously learned shape-pair. This "parts-beget-parts" effect suggests that statistical learning, in combination with prior knowledge, can represent objects as a coherent whole and also as a spatial configuration of parts by bootstrapping multi-layer hierarchical structures.
  Executive function (EF) difficulties characterise a number of psychiatric conditions and EF impairment may be a predisposing factor and/or consequence of anxiety and stress. The aim of the study was to examine EF factors in a mixed clinical cohort (Autism Spectrum Disorder and Social Anxiety Disorder) characterised by social impairment and investigate the influence of trait anxiety and state-based depression, anxiety and stress.
 
  In Study 1, a factor analysis identified EF and non-EF latent factor structures (N=205). In Study 2, (N=137) multiple regression analyses investigated the association between trait anxiety and state based depression, anxiety and stress, on EF and non-EF cognitive domains and on the two composite indices of the Behavioural Rating Inventory of Executive Function (BRIEF).
 
  Trait anxiety was associated with better performance on neuropsychological measures of EF while state-based stress was associated with lower EF performance. A dissociation was observed between trait anxiety and state stress on the two behavioural indices of the BRIEF. Depression, anxiety and stress did not predict performance on non-EF cognitive domains.
 
  The cross-sectional design precludes cause-effect conclusions, further only self-report measures of affect were utilised and our performance measures of EF did not include a working memory test.
 
  The results demonstrate that trait anxiety and state-based stress influence EF processes across disorders with social impairment. The transdiagnostic efficacy of this finding can facilitate remediation strategies, it may also contribute to individuals with Autism Spectrum Disorder gaining better access to mental health services.
 The results demonstrate that trait anxiety and state-based stress influence EF processes across disorders with social impairment. The transdiagnostic efficacy of this finding can facilitate remediation strategies, it may also contribute to individuals with Autism Spectrum Disorder gaining better access to mental health services.It is widely believed that better access to fast food (FF) outlets increases FF consumption and thus the risk of obesity; yet, thus far, there are limited results to support this conclusion in Asian countries. A recent study by Hall and his colleagues (in press) examined the cross-sectional relationship between FF restaurant density and the likelihood of being overweight or obese among 1388 female Filipino migrant workers living in Macao, China. It found that FF restaurant density within a 0.5-mile buffer zone around one's home was significantly associated with a 7% increase (95% CI 1%-14%) in the odds of being overweight or obese in this population. Based on these findings, the authors suggested improving access to healthy foods as one of the means to fight the obesity epidemic. The current article examines literature 1) on the relationship between obesity, FF consumption, and access to FF outlets; 2) on different measures of access to FF outlets; 3) on potential confounders and effect modifiers such as neighborhood deprivation and transportation; and 4) on challenges and implications for researchers and policymakers. Considering the growing consumption of FF and obesity rates in many countries especially in developing countries, it is important to regulate the FF industry and help consumers improve their related knowledge and behaviors. We also recommend that government policies abate obesogenic environments and thus curb the obesity epidemic in the future.
  Diclofenac (DIC) is a Nonsteroidal anti-inflammatory drug (NSAID) and consumption of this drug creates side effects such as renal injury. The purpose of this work was to assess the influences of gallic acid (GA) on DIC-induced renal injury in rats.
 
  Rats were segregated into five groups. Group 1, control group; Group 2 received DIC-only (50mg/kg bw, i.p.) for 7 consecutive days; Groups 3, received GA-only (100mg/kg bw, po) for 7 consecutive days; group 4 received DIC (50mg/kg bw, i.p.) plus GA (50mg/kg, po) for 7 consecutive days and group 5 received DIC (50mg/kg bw, i.p.) plus GA (100mg/kg, po) for 7 consecutive days.
 
  The data indicated that the levels of the serum protein carbonyl, sGOT, sGPT, urea, creatinine, uric acid, nitrite content, MDA, serum IL-1β, and the renal IL-1β gene expression were remarkably increased in DIC-only treated animals compared to control group. In the other hand, treatment with gallic acid led to significant improvements in abnormalities of DIC-induced oxidative stress and serum biochemical parameters.  https://www.selleckchem.com/products/afuresertib-gsk2110183.html  Histological changes were also ameliorated by GA oral administration.
 
  The results indicated that oral injection of GA could alleviate the noxious effects of DIC on the antioxidant defense system and renal tissue.
 The results indicated that oral injection of GA could alleviate the noxious effects of DIC on the antioxidant defense system and renal tissue.