https://www.selleckchem.com/products/lxh254.html Pancreatic cystic lesions are an increasingly common clinical finding. They represent a heterogeneous group of lesions that include two of the three known precursors of pancreatic cancer, intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN). Given that approximately 8% of pancreatic cancers arise from these lesions, careful surveillance and timely surgery offers an opportunity for early curative resection in a disease with a dismal prognosis. This review summarizes the current evidence and guidelines for the diagnosis and management of IPMN/MCN. Current pre-operative diagnostic tests in pancreatic cysts are imperfect and a proportion of patients continue to undergo unnecessary surgical resection annually. Balancing cancer prevention while preventing surgical overtreatment, continues to be challenging when managing pancreatic cysts. Cyst fluid molecular markers, such as KRAS, GNAS, VHL, PIK3CA, SMAD4 and TP53, as well as emerging endoscopic technologies such as needle-based confocal laser endomicroscopy and through the needle microbiopsy forceps demonstrate improved diagnostic accuracy. Differences in management and areas of uncertainty between the guidelines are also discussed, including indications for surgery, surveillance protocols and if and when surveillance can be discontinued.This study aimed to longitudinally analyze the role played by two emotional regulation strategies (cognitive reappraisal and expressive suppression), through the mediating effect of engagement in pleasant activities during lockdown, in changes in affective and cognitive happiness in comparison with pre-pandemic levels. Eighty-eight participants from a community sample were evaluated at two timepoints. At timepoint 1 (before the COVID-19 pandemic), participants were evaluated on emotional regulation and cognitive and affective happiness. At timepoint 2 (during the COVID-19 lockdown), participants were evaluate