Objectives To investigate the effect of fixed and adaptive microphone directionality on speech reception threshold (SRT) in noise when compared to omnidirectional mode in unilateral cochlear-implant (CI) use for three different CI systems.Methods Twenty-four CI recipients with bilateral severe-to-profound hearing loss participated in the study. Eight recipients of each CI system were enrolled, and their SRT in noise was measured when the speech and noise signals were co-located in the front to serve as a baseline. The acute effect of different microphone directionalities on SRT in noise was measured with the noise emanating at 90° in the horizontal plane from the side of the CI sound processor (S0NCI).Results When compared to the baseline condition, the individual data revealed fairly similar patterns within each CI system. In the S0NCI condition, the average improvement in SRT in noise for fixed and adaptive directionalities over the omnidirectional mode was statistically significant and ranged from 1.2 to 6.0 dB SNR and from 3.7 to 12.7 dB SNR depending on the CI system, respectively.Discussion Directional microphones significantly improve SRT in noise for all three CI systems. However, relatively large differences were observed in the directional microphone efficacy between CI systems.During 20 m shuttle tests, obese adolescents may have difficulty achieving maximum cardiorespiratory performance due to the presence of braking-relaunch phases (BRP). Nineteen obese adolescents aged 15.2 ± 1.5 years (body mass index [BMI] = 39.7 ± 5.9 kg.m-2) performed three graded walking exercises on a 50 m track at speeds between 3 and 6 km/h a continuous-straight-line protocol (C), a continuous protocol that required turning back every 30 sec (C-BRP) and an intermittent protocol that consisted of successively walking then resting for 15 sec (15-15). Oxygen uptake (VO2), aerobic cost of walking (Cw), ventilation (VE) and rating of perceived exertion (RPE) were measured at each stage during the protocols. During C-BRP, the responses were not significantly higher compared with C (p > 0.30). During 15-15, the VO2, Cw and VE were ~ 15 to 25% lower than during C beginning at 4 km/h (p  less then  0.05). In obese adolescents, the respiratory impact of sudden directional changes during the 20 m shuttle-type test appeared to be minor at walking speeds. During the 15-15 test, the intensity increases more progressively, and this design may encourage obese adolescents to walk further than during a continuous test.Background The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) is a multicenter, randomized, placebo-controlled trial, designed to test whether a statin medication can prevent cardiovascular disease in people with HIV. REPRIEVE recently completed enrollment of 7557 participants at over 100 clinical sites globally. Participant groups of focus were women, and racial and ethnic minorities.Objective To describe recruitment methods and strategies developed by the REPRIEVE Clinical Coordinating Center (CCC) and share best practices learned from the recruitment process.Methods Enrollment targets were agreed upon with the primary funder, the National Heart, Lung, and Blood Institute (NHLBI) and were milestone driven. Milestones included number of sites activated, number of participants enrolled within specific time frames, and proportion of women and minorities enrolled. Strategies to achieve these milestones included structured interviews with site-designated REPRIEVE Recruitment Champions to develop best practices, development of a multimedia campaign, and site level recruitment support.Results Recruitment initiated March, 2015 and completed March, 2019. The final accrual target was 7500 participants over 48 months. The trial met this target within the time specified. Overall, 10,613 screens were completed, 48% of participants enrolled from sites outside of North America, 32% were female, 44% were Black or African American, and 25% were Hispanic or Latino.Conclusions REPRIEVE met its overall projected recruitment goal by using multiple, simultaneous strategies to specifically target a diverse population including minority subgroups. REPRIEVE benefited from the development of recruitment strategies with clear targets and communication of accrual targets to study teams.Background It is assumed that the production of cortisol is modulated by light exposure. While initial evidence supports this principal effect, the specific effect of light (intensity and wavelength) onto the cortisol stress response is still not completely understood.Method One between-subject experiment was conducted in a standardized sleep laboratory setting to investigate the effect of light intensity (dim white vs. bright white light) and spectral composition (red vs. blue) on the cortisol response after the Maastricht Acute Stress Test (MAST). 112 healthy young males (24.83 ± 4.10 years of age) were randomly assigned to one of the four light conditions. Across conditions, light exposure was conducted for one-hour post-awakening and the light effect was measured based on eight saliva samples.Results The analysis indicates significant main effects for time and light condition as well as a significant interaction effect. Notably, bright light exposure evoked the highest cortisol levels when compared to dim white, red, and blue light.Conclusion Our findings illustrate the crucial role of light intensity and wavelength for the cortisol stress response, in line with current theoretical knowledge of underlying neurobiological mechanisms.Lay Summary Effects of different light sources were tested on healthy male adults in the morning after a stress test. Their stress responses showed that a bright light exposure increased the stress hormone level greatest compared to dim white, red or blue light sources. Findings point towards the crucial role of light intensity associated with the hormonal stress response.Aim To investigate the effect of tadalafil in rats administered with daily dutasteride.Methods Twenty-four Sprague-Dawley male rats were allocated to three groups as control (group C), dutasteride (group D) and dutasteride plus tadalafil (group D + T). After a month of treatment, serum samples were obtained from rats to measure dihydrotestosterone and total testosterone. Nitric oxide (NO) synthase (NOS) immunoreactivity and levels of NOS enzyme isoforms, NO and cyclic guanosine monophosphate (cGMP) were evaluated in the harvested penile tissues.  https://www.selleckchem.com/products/mlt-748.html  Also, corporal smooth muscle and collagen were examined.Results Staining intensities of neuronal NOS and endothelial NOS were significantly lower in group D (p .05). Group D and group D + T had significantly decreased dihydrotestosterone and increased testosterone, compared to group C (p  less then  .001). They were similar between group D and group D + T.Conclusion Daily treatment with tadalafil improves dutasteride-induced changes in rat penis.