ntrol for both age and BMI. Researchers should also compare ratio approaches with multivariate techniques, such as geometric morphometrics, to examine whether the latter have greater utility for understanding the evolution of facial sexual dimorphism.The study of super-gentrification has important practical significance for maintaining social fairness, spatial justice and achieving sustainable urban development. In this article, 23 driving factors influencing super-gentrification are identified by literature research and Delphi method. Then, the 23 driving factors affecting super-gentrification are divided into four dimensions political, economic, social and spatial dimension. On this basis, hypotheses are proposed and a structural equation model is established. Then, SPSS 25.0 and AMOS 24.0 software are used to test the reliability and validity of the questionnaire data, and the model results are fitted and modified. Finally, the optimization model and path coefficient of super-gentrification driving factors are calculated. The results of the study show that political factors, economic factors, social factors, and spatial factors, all play a positive role in the development of super-gentrification. Social factors are the fundamental factors to promote super-gentrification, political factors, economic factors, and spatial factors also play a key role in the super-gentrification process.
  Long-term viral load (VL) suppression among HIV-positive, reproductive-aged women on ART is key to eliminating mother-to-child transmission (MTCT) but few data exist from sub-Saharan Africa. We report trends in post-partum VL in Malawian women on ART and factors associated with detectable VL up to 24 months post-partum.
 
  1-6 months post-partum mothers, screened HIV-positive at outpatient clinics in Malawi, were enrolled (2014-2016) with their infants. At enrollment, 12- and 24-months post-partum socio-demographic and PMTCT indicators were collected. Venous samples were collected for determination of maternal VL (limit of detection 40 copies/ml). Results were returned to clinics for routine management.
 
  596/1281 (46.5%) women were retained in the study to 24 months. Those retained were older (p<0.01), had higher parity (p = 0.03) and more likely to have undetectable VL at enrollment than those lost to follow-up (80.0% vs 70.2%, p<0.01). Of 590 women on ART (median 30.1 months; inter-quartile range 26ncy and post-partum.
 Detectable virus early post-partum strongly increases risk of ongoing post-partum viremia. Due to high loss to follow-up, the true incidence of detectable VL over time is probably underestimated. These findings have implications for MTCT, as well as for the mothers, and call for intensified VL monitoring and targeted adherence support for women during pregnancy and post-partum.
  The two biomarkers 2-[18F]FDG-PET and cerebrospinal fluid biomarkers are both recommended to support the diagnosis of Alzheimer's disease. However, there is a lack of knowledge for the comparison of the two biomarkers in a routine clinical setting.
 
  The aim was to compare the clinical impact of 2-[18F]FDG-PET and cerebrospinal fluid biomarkers on diagnosis, prognosis, and patient management in patients suspected of Alzheimer's disease.
 
  Eighty-one patients clinically suspected of Alzheimer's disease were retrospectively included from the Copenhagen Memory Clinic. As part of the clinical work-up all patients had a standard diagnostic program examination including MRI and ancillary investigations with 2-[18F]FDG-PET and cerebrospinal fluid biomarkers. An incremental study design was used to evaluate the clinical impact of the biomarkers. First, the diagnostic evaluation was based on the standard diagnostic program, then the diagnostic evaluation was revised after addition of either cerebrospinal fluid biomamore significant value in corroborating the diagnosis of Alzheimer's disease compared to 2-[18F]FDG-PET.
 The two biomarkers had similar clinical impact on diagnosis, but cerebrospinal fluid biomarkers had a more significant value in corroborating the diagnosis of Alzheimer's disease compared to 2-[18F]FDG-PET.How and why customers engage with mobile travel apps is vital to mobile marketing of travel-related companies. This paper discusses the antecedents and consequences of mobile travel app engagement. Specifically, this study aims to understand how travel app attributes stimulate mobile travel app engagement and lead to purchase intention. A research model is established based on the Stimulus-Organism-Response (S-O-R) model and the model is tested by Partial Least Squares Path Modeling (PLS-PM). The results show that ease of use, compatibility, and UI attractiveness positively influence mobile travel app engagement, and in turn, affect purchase intention. Furthermore, a multi-group analysis shows that the attributes affecting mobile travel app engagement differ across different customer groups. This paper discusses some theoretical and practical implications.We study the health trajectories of the population aged over 60, comparing between one European and two Latin American countries (Spain, Chile and Costa Rica) which have similar longevity patterns. Our focus is on functional limitation and mortality risks, considering differences by gender, education and social participation. Data come from national panel surveys (EPS, CRELES, SHARE). Multistate modelling is used to estimate transition probabilities between two health states healthy to unhealthy, unhealthy to healthy as well as the transition to death from healthy or unhealthy states, to estimate the duration of stay in a specific state (computing healthy and unhealthy life expectancies) and the effect of the selected covariates. Results show that older Costa Ricans have the smallest gender gap in life expectancy but women have a lower healthy life expectancy compared to those in Chile and Spain.  https://www.selleckchem.com/products/mk-0159.html  Participation in social activities leads to higher healthy life expectancy among the elderly in Costa Rica and Spain, whilst there were no relevant educational differences observed in longevity in the analysed countries. To conclude despite the different patterns observed in health transitions and survival across the three countries, social participation is associated with greater health and longevity among people of old age, with little effect coming from educational attainment. Public policies should therefore be aimed at reducing unhealthy life years and dependency at advanced ages by promoting more engagement in social activities, especially among vulnerable groups who are more likely to experience impairment from a younger age.