https://www.selleckchem.com/products/Y-27632.html The biomedical application of nanoparticles (NPs) for diagnosis and therapy is considerably stalled by their inefficient cellular internalization. Many strategies to overcome this obstacle have been developed but are not generally applicable to different NP systems, consequently underlining the need for a universal method that enhances NP entry into cells. Here we describe a method to increase NP cellular uptake via strand hybridization between DNA-functionalized NPs and cells that bear the respective complementary sequence incorporated into the membrane. By this, the NPs bind efficiently to the cellular surface enhancing internalization of three completely different NP types DNA tetrahedrons, gold (Au) NPs, and polystyrene (PS) NPs. We show that our approach is a simple and generalizable strategy that can be applied to virtually every functionalizable NP system.Photocatalysis-assisted water splitting using semiconductor materials greatly depends on the bandgap size and the alignment of band edges relative to the reaction potentials. We used ab initio computational methods to show that the biaxial strain on [100]-oriented orthorhombic NaTaO3 thin films grants the modulation of surface states, favoring either the hydrogen evolution reaction (HER) or the oxygen evolution reaction (OER), which basically rules the perovskite photocatalytic performance. Under compression, the outermost TaO6 and TaO4 polyhedra become more distorted, and electrostatic repulsion increases the energy of Ta 5d surface states. As they overcome the O2/H2O potential, they cease to contribute to the OER. At the same time, the H+/H2 remains below the conduction band, leveraging the HER over the OER. The tensile strain lowers the outermost polyhedra distortions, stabilizing both Ta 5d surface and conduction band states, and increasing the charge centered around surface Ta atoms. Consequently, the bands are better aligned with O2/H2O and H+/H2 potent