https://www.selleckchem.com/products/Nimodipine(Nimotop).html Carbo -benzene is an aromatic molecule devised by inserting C 2 units within each C-C bond of the benzene molecule. By integrating the corresponding carbo -quinoid core as bridging unit in a p -extended tetrathiafulvalene (exTTF), it is shown that a carbo -benzene ring can be reversibly formed by electrochemical reduction or oxidation. The so-called carbo -exTTF molecule was thus experimentally prepared and studied by UV-visible absorption spectroscopy and cyclic voltammetry, as well as by X-ray crystallography and by scanning tunneling microscopy (STM) on a surface of highly oriented pyrolytic graphite (HOPG). The molecule and its oxidized and reduced forms were subjected to a computational study at the density functional theory (DFT) level, supporting carbo -aromaticity as a driving force for the formation of the dication, radical cation, and radical anion. By allowing co-planarity of the dithiolylidene rings and carbo -quinoidal core, carbo -exTTFs present a promising new class of redox-active systems. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Aggressive morphologic variants of mantle cell lymphoma (MCL), including blastoid and pleomorphic (B/P-MCL), are rare and associated with poor clinical outcomes. The genomic landscape of these variants remains incompletely explored. In this multi-institutional study, we describe recurrent mutations and novel genomic copy number alterations (CNAs) in B/P-MCL, using next generation sequencing and SNP-array. Chromothripsis, a recently described phenomenon of massive chromosomal rearrangements, was identified in eight of 13 (62%) B/P MCL cases, and a high degree of genomic complexity with frequent copy number gains and losses was also seen. In contrast, a comparative cohort of nine cases of conventional MCL (C-MCL) showed no chromothripsis and less complexity. Twelve of 13 (92%) B/P-MCL cases showed loss of CDKN2A/B (6 biallelic and 6 monoallelic losses); whi