09, 95%CI(1.04-1.14) and OR 1.34, 95%CI(1.24-1.44) respectively]. The estimates remained unchanged after adjustment for several confounders (such as maternal age, BMI, parity, prior CS, smoking, occupation and country of birth) and potential covariates (such as delivery mode, polyhydramnion, preterm delivery, labor dystocia and infant birthweight above 4000g). CONCLUSIONS Higher risk for PPH was observed both among women treated with SSRI during pregnancy, as well as women with prior or current psychiatric illness. This article is protected by copyright. All rights reserved.AIMS To increase biodegradation of phenanthrene (PHE), pyrene (PYR) and fluoranthene (FLU) through mixed cultures of polycyclic aromatic hydrocarbon (PAH)-degrading bacteria, using modified repeated batch fermentation.  https://www.selleckchem.com/products/gpna.html  METHODS AND RESULTS Novel bacterial strains of Pseudomonas putida, Pseudomonas sp. and Ralstonia eutropha were cultivated and the biodegradation and conversion of mixed PAH to medium chain length-polyhydroxyalkanoates (MCL-PHA) was determined. The highest degradation of PAH (100%) and PHA production (50.0%) was obtained in medium containing 30 mmol/l of mixed PAH after three cycles of repeat batch fermentation. The concentration of PAH in the reactor was increased from 30 to 90 mmol/l with repeat additions of PAH, and bacteria were able to produce PHA at 40% of cell dry mass (CDM). The MCL-PHA were identified by gas chromatography-mass spectroscopy (GC-MS), with the 3-hydroxydecanoate (3-HD) monomer higher than 75 mol%. CONCLUSIONS This study demonstrated that the biodegradation of PHE, PYR and FLU was enhanced by modified repeated batch fermentation using a mixed culture of bacteria. In addition, this fermentation strategy also increased production of PHA, with an increase of monomer composition. SIGNIFICANCE AND IMPACT OF THE STUDY This was the first study to describe enhance the degradation of mixed solutions of PHE, PYR and FLU, and PHA production, using novel mixed bacterial cultures and modified repeated batch fermentation. The MCL-PHA formed had uniquely high 3-HD content. This article is protected by copyright. All rights reserved.The recently emerged 2019 Novel Coronavirus (SARS-CoV-2) and associated COVID-19 disease cause serious or even fatal respiratory tract infection and yet no approved therapeutics or effective treatment is currently available to effectively combat the outbreak. This urgent situation is pressing the world to respond with the development of novel vaccine or a small molecule therapeutics for SARS-CoV-2. Along these efforts, the structure of SARS-CoV-2 main protease (Mpro) has been rapidly resolved and made publicly available to facilitate global efforts to develop novel drug candidates. Recently, our group has developed a novel deep learning platform - Deep Docking (DD) which provides fast prediction of docking scores of Glide (or any other docking program) and, hence, enables structure-based virtual screening of billions of purchasable molecules in a short time. In the current study we applied DD to all 1.3 billion compounds from ZINC15 library to identify top 1,000 potential ligands for SARS-CoV-2 Mpro protein. The compounds are made publicly available for further characterization and development by scientific community. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.OBJECTIVES To evaluate the efficacy and safety of a novel fixation technique referred to as the dynamic anterior plate-screw system for quadrilateral plate (DAPSQ) for complex acetabular fractures with quadrilateral plate involvement through the single ilioinguinal approach. METHODS A total of 32 patients with acetabular fractures, selected between January 2009 and March 2016, were managed by DAPSQ with "quadrilateral screws" through single ilioinguinal approach. The primary outcomes measure was the reduction quality evaluated according to the Matta radiological criteria, and the functional outcomes were evaluated by the modified Merle d'Aubigné score at the last follow-up. Secondary outcomes were postoperative complications and intraoperative conditions included, for instance, operation time and blood loss. RESULTS Of these 32 consecutive patients, 19, 9, and 4 were classified as both columns, anterior column posterior hemi-transverse, and T-shaped fractures, respectively, and with an average of 47 months' follow-up. Anatomic reduction was obtained in 19 cases (59%), imperfect reduction in 9 cases (28%), and poor reduction in 4 cases (13%). The modified Merle d'Aubigné scores were excellent in 15 cases (47%), good in 13 cases (41%), fair in 2 cases (6%), and poor in 2 cases (6%). Three cases sustained temporary lateral femoral cutaneous nerve injuries. One patient had a superficial wound infection that resolved after debridement. Five patients had posttraumatic arthritis; one of them underwent total hip arthroplasty at 46 months. No cases had quadrilateral screws entering the hip joint. CONCLUSION The use of DAPSQ with quadrilateral screws is an effective and safe choice for complex acetabular fractures with quadrilateral plate involvement through the single ilioinguinal approach. © 2020 The Authors. Orthopaedic Surgery published by Chinese Orthopaedic Association and John Wiley & Sons Australia, Ltd.Most of current nanomedicines are administrated intravenously to favour tumor accumulation via enhanced permeability and retention (EPR) effect, which, however, suffers from a number of drawbacks such as low drug bioavailability and severe side effect. Inspired from the advances in nutriology, in this work, we have constructed a doxorubicin(Dox)-based liposomal nanosystem, whose component is analogous to that of FDA-approved cancer nanomedicine Doxil ® , for tumor-specific chemotherapy by enabling differential stress sensitization between cancer and normal cells for restricting the chemodrug toxicity exclusively in tumor regions. In detail, 2-Deoxy-D-glucose (2DG) was loaded in the nanoliposome to inhibit glycolysis of cancer cells, which works in synergy with the co-loaded chemodrug Dox to promote mitochondrial depolarization and subsequent apoptosis. In the meantime, the starvation effect of 2DG is able to counteract the toxicity of Dox in normal cells and thus mitigates the harmful side effect of chemotherapy.