Microplastics have received growing attention as carriers of organic pollutants in the water environment. To better understand the contribution of hydrophobic interaction, hydrogen-bonding interaction, π-π interaction and electrostatic interaction on the adsorption of hydrophilic compounds on microplastics and their adsorption behavior in natural waters, polyethylene terephthalate (PET, TCP. This study provides insights into the fate of CPs in the presence of microplastics and suggests that the potential risks posed by CPs and microplastics to aqueous ecosystems merit further investigation.Several epidemiological studies have evaluated the fractional exhaled nitric oxide (FeNO) of ambient air pollution but the results were controversial. We therefore conducted a systematic review and meta-analysis to investigate the associations between short-term exposure to air pollutants and FeNO level. We searched PubMed and Web of Science and included a total of 27 articles which focused on associations between ambient air pollutants (PM10, PM2.5, black carbon (BC), nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3)) exposure and the change of FeNO. Random effect model was used to calculate the percent change of FeNO in association with a 10 or 1 μg/m3 increase in air pollutants exposure concentrations. A 10 μg/m3 increase in short-term PM10, PM2.5, NO2, and SO2 exposure was associated with a 3.20% (95% confidence interval (95%CI) 1.11%, 5.29%), 2.25% (95%CI 1.51%, 2.99%),4.90% (95%CI 1.98%, 7.81%), and 8.28% (95%CI 3.61%, 12.59%) change in FeNO, respectively. A 1 μg/m3 increase in short-term exposure to BC was associated with 3.42% (95%CI 1.34%, 5.50%) change in FeNO. The association between short-term exposure to O3 and FeNO level was insignificant (P＞0.05). Future studies are warranted to investigate the effect of multiple pollutants, different sources and composition of air pollutants on airway inflammation.Fluorine, an environmental toxicant in our daily life, has been reported to have adverse effects on nervous system. Previous studies demonstrated that fluorine exposure could induce brain injury in fish and human. However, the possible mechanism remains unclear. In the present study, we aimed to reveal the mechanism of fluorine exposure on brain injury of common carp through transcriptome analysis. In the fluorine-exposed carp, 444 brain genes were up-regulated, whereas 742 genes were down-regulated. DNA-templated (regulation of transcription) and multicellular organism development in the GO function annotation accounted for the most biological processes. Nucleus and membrane accounted for the most cellular components and DNA binding and metal ion binding accounted for the most molecular function. Meanwhile, 196 metabolic pathways were identified in Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway significant enrichment analysis, including long-term depression, Cushing syndrome, nuclear receptors, vascular smooth muscle contraction, Ion channels, and other pathways. Furthermore, we found that the up-regulated and down-regulated trends were similar between the quantitative real-time-PCR and RNA-Seq results, which indicate the transcriptome sequencing data is reliable. In conclusion, our data may provide insights into the mechanisms underlying brain injury induced by fluorine exposure.Purpose We determined whether factors related to epilepsy are associated with a risk of suicide independent of depression in persons with epilepsy. Method This cross-sectional study included adults with epilepsy.  https://www.selleckchem.com/products/sn-38.html  Suicidality and depression were assessed with the Mini International Neuropsychiatric Interview (MINI). Patients were divided into two age groups (≤ 40 vs. > 40 years). Presence of suicide risk was defined as a MINI suicidality score ≥ 1. A stepwise logistic regression analysis was conducted. Results A total of 212 participants were recruited (52.4 % men). Suicide risk and depression were noted in 31.6 % and 22.2 % of participants, respectively. An antiepileptic drug load ≥ 1 (odds ratio [OR], 4.093-4.152) was significantly associated with a risk of suicide, independent of depression (OR, 5.794), and a past or family history of psychiatric disorders (OR, 2.677). When stratified by age, pregabalin usage (OR, 13.403) in the younger group and high seizure frequency (≥ 1 per month) (OR, 5.748) in the older group were associated with a risk of suicide independent of current depression. Conclusion The risk of suicide in persons with epilepsy may be associated with epilepsy-related factors such as a high antiepileptic drug load, frequent seizures, and use of pregabalin, independent of depression. Such risk factors may vary depending on the age of the patient.Purpose The aim of this study is to investigate the clinical characteristics of epilepsy affecting the progression of motor disabilities in cerebral palsy (CP). Methods CP patients were retrospectively followed for 15 years from January 2005 to January 2020, and the following items were collected from the medical records sex, age, etiology, and the clinical features of epilepsy. All patients were divided into two groups of unchanging CP and worsening CP based on whether or not they showed progression of motor disabilities during 15 years' hospitalization, respectively. Results In total, we evaluated 65 CP cases who had been continuously hospitalized for more than 15 years. Twenty-eight patients had unchanging CP, showing no changes in motor disabilities for 15 years, while 37 had worsening CP, showing a worsening of the motor disabilities over 15 years. Most epilepsy patients with unchanging CP showed their first seizure onset during the first year of life (62.5 %), while the epilepsy patients with worsening CP showed the onset from 1 year of age (70.8 %) (p = 0.03). Daily or weekly seizure frequency was significantly more apparent in cases of worsening CP (25.0 %) than in cases of unchanging CP (p = 0.03). Conclusion The younger the age at the time of seizure onset, the less severe the consequences appear to be. Furthermore, increased seizure frequency seems to be directly related to reduced functional connections involving the whole brain. These two factors result in progressive motor disabilities, including intellectual, sensory and behavioral difficulties in CP patients.