To ensure adequate reliability (i.e., internal consistency), it is common in studies using event-related brain potentials (ERPs) to exclude participants for having too few trials. This practice is particularly relevant for error-related ERPs, such as error-related negativity (ERN), where the number of recorded ERN trials is not entirely under the researcher's control. Furthermore, there is a widespread practice of inferring reliability based on published psychometric research, which assumes that internal consistency is a universal property of ERN. The present, preregistered reliability generalization study examined whether there is heterogeneity in internal consistency estimates of ERN scores and whether contextual factors moderate reliability. A total of 189 internal consistency estimates from 68 samples nested within 43 studies (n = 4,499 total participants) were analyzed. There was substantial heterogeneity in ERN score internal consistency, which was partially moderated by the type of paradigm (e.g., Stroop, flanker), the clinical status of the sample, the ocular artifact correction procedure, measurement sensors (single versus cluster), and the approach to scoring and estimating reliability, suggesting that contextual factors impact internal consistency at the individual study level. Age, sex, year of publication, artifact rejection procedure, acquisition system, sample type (undergraduate versus community), and length of mean amplitude window did not significantly moderate reliability. Notably, the overall estimated reliability of ERN scores was below established standards. Recommendations for improving ERN score reliability are provided, but the routine failure of most ERN studies to report internal consistency represents a substantial barrier to understanding the factors that impact reliability. © 2020 Society for Psychophysiological Research.OBJECTIVES Ultrasound (US) is useful for diagnosing full-thickness rotator cuff tears and high-grade partial-thickness bursal-side tears. However, anisotropy artifacts make it difficult to identify partial articular supraspinatus tendon avulsion (PASTA) by US. This study was performed to determine the diagnostic accuracy of US for PASTA and to uncover sensitive findings that could aid decisions to repair. METHODS Patients who underwent preoperative US examinations and supraspinatus tendon confirmation by arthroscopic examinations were enrolled. We analyzed 52 PASTA cases involving greater than 50% thickness of the tendon and 52 age- and sex-matched cases with an intact supraspinatus. Two orthopedic surgeons blinded to the diagnosis interpreted US videos of the supraspinatus tendon. Six findings (echo defect, tendon delamination, echo change, tendon thickness, tendon fiber pattern, and cartilage interface sign) were assessed. We calculated the sensitivity, specificity, and accuracy for each US finding. RESULTS The cases consisted of 46 men and 58 women. The US diagnosis of PASTA showed sensitivity of 64.7%, specificity of 94.1%, and accuracy of 79.4%. The echo change in the short axis showed the highest sensitivity. Thinning and delamination showed the highest specificity of 100%. In contrast to previous reports, the sensitivity of the cartilage interface sign was low in both long-axis images (17.6%) and short-axis images (29.4%). CONCLUSIONS Preoperative diagnostic US to aid decisions regarding PASTA repair showed high specificity (94.1%) and moderate accuracy (79.4%). However, the sensitivity was only 64.7% and was affected by the examiner's experience with US. © 2020 by the American Institute of Ultrasound in Medicine.To explain how social movements and organizations changed in the context of the Rio Doce socio-environmental disaster, this article identifies a process of organizational innovation. The research is based on documental data and interviews with activists over the three years of the disaster. The main argument is that organizational innovation consists of changes in organizational forms and repertoires of collective action, based on existing organizational models and tactics. On the one hand, the innovation occurred through the territorialization of novel organizational forms, intermediated by social movements which act as incubators. On the other, it consisted of the combination between extrainstitutional, institutional, and multi-scalar repertories and in the innovation in tactics and performances. Mechanisms of adaptation, imitation, and negotiated diffusion are identified which operated in this innovation process. It is argued that the organizational innovation of social movements was propelled by political constraints of disaster governance which pushed them to innovation, in addition to role of preexisting organizations. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Despite the administration of new effective drugs in recent years, relapse and drug resistance are still the main obstacles in multiple myeloma (MM) treatment, making MM an incurable disease. To overcome drug resistance in MM, it is critical to understand the underlying mechanisms of malfunctioning gene expression and develop novel targeted therapies. During the past few decades, with the discovery and characterization of noncoding RNAs (ncRNAs), the landscape of dysregulated ncRNAs of cancers as well as their biological and pathobiological functions in tumorigenesis and drug resistance have been recognized. Studies about ncRNAs improved the understanding of variations of drug response among individuals at a level distinguished from genetic polymorphism, and provided with new orientations for targeted therapies. In this review, we will summarize the emerging impact and underlying molecular mechanisms of the most relevant classes of ncRNAs in drug resistance of MM, and discuss the potential as well as strategies of treating ncRNAs as therapeutic targets. © 2020 Wiley Periodicals, Inc.Although economists have suggested that humans generally prioritize maximizing their own self-interest rather than others' when distributing rewards, recent psychological studies have shown that people are hyperaltruistic when allocating physical harm to themselves and others during moral decision-making. However, little is known about how the neurocognitive mechanisms underlying self-relevance modulate this behavioral tendency under different degrees of physical harm. This study adopted a moral decision-making task to investigate behavioral and neural processes during moral decision-making involving different levels of self-relevance and physical harm.  https://www.selleckchem.com/products/tegatrabetan.html  Event-related potentials were measured while participants made trade-offs of different monetary gains for themselves against painful electric shocks experienced by the receivers (self, friend, or stranger). These results suggest that early anterior N1, indexing fast and automatic moral intuitional process, decreased during the strong conflict trade-off decisions involving strong painful electric shocks and much monetary gains.